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Some cross-talks between immune cells and epilepsy should not be forgotten.

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Title: Some cross-talks between immune cells and epilepsy should not be forgotten.
Authors: Wang, Hong, Liu, Sibo, Tang, Zeyao, Liu, Jinjie
Source: Neurological Sciences. Dec2014, Vol. 35 Issue 12, p1843-1849. 7p.
Subjects: Biological crosstalk, Immune system, Blood cells, People with epilepsy, Brain physiology, Neurotransmitters, Carrier proteins, Neural physiology
Abstract: Recent studies have reported that immune cells were not always found in brain specimens from epileptic patients, then should we stop investigating the relationship between these cells and epilepsy? The answer is no! In addition to immunocyte infiltration in brain parenchyma, a flurry of papers have demonstrated that there were significant alterations in peripheral blood cells (PBCs) immediately after seizure onset, especially changes in some specific transporters of neurotransmitters expressed on the membrane of immunocyte. These transporters may regulate neuronal excitability in mature neurons. Besides, many researchers did find activated leukocytes adhered to the endothelium of blood brain barrier or infiltrated into the brain parenchyma in several types of epilepsy both in human and animal studies; moreover, it is worth noting that different immune cells play different roles in epilepsy development, which was indicated by in vitro and in vivo evidence. This review is going to summarize available evidence supporting changes in PBCs after seizures, and will also focus on some specific effects of immune cells on epilepsy development. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Some cross-talks between immune cells and epilepsy should not be forgotten.
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  Data: <searchLink fieldCode="AR" term="%22Wang%2C+Hong%22">Wang, Hong</searchLink><br /><searchLink fieldCode="AR" term="%22Liu%2C+Sibo%22">Liu, Sibo</searchLink><br /><searchLink fieldCode="AR" term="%22Tang%2C+Zeyao%22">Tang, Zeyao</searchLink><br /><searchLink fieldCode="AR" term="%22Liu%2C+Jinjie%22">Liu, Jinjie</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Dec2014, Vol. 35 Issue 12, p1843-1849. 7p.
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  Data: Recent studies have reported that immune cells were not always found in brain specimens from epileptic patients, then should we stop investigating the relationship between these cells and epilepsy? The answer is no! In addition to immunocyte infiltration in brain parenchyma, a flurry of papers have demonstrated that there were significant alterations in peripheral blood cells (PBCs) immediately after seizure onset, especially changes in some specific transporters of neurotransmitters expressed on the membrane of immunocyte. These transporters may regulate neuronal excitability in mature neurons. Besides, many researchers did find activated leukocytes adhered to the endothelium of blood brain barrier or infiltrated into the brain parenchyma in several types of epilepsy both in human and animal studies; moreover, it is worth noting that different immune cells play different roles in epilepsy development, which was indicated by in vitro and in vivo evidence. This review is going to summarize available evidence supporting changes in PBCs after seizures, and will also focus on some specific effects of immune cells on epilepsy development. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10072-014-1955-6
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        Text: English
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        Type: general
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      – SubjectFull: Blood cells
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      – SubjectFull: People with epilepsy
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              Text: Dec2014
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