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Vitamin D receptor polymorphisms and susceptibility to Parkinson's disease and Alzheimer's disease: a meta-analysis.

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Title: Vitamin D receptor polymorphisms and susceptibility to Parkinson's disease and Alzheimer's disease: a meta-analysis.
Authors: Lee, Young, Kim, Jae-Hoon, Song, Gwan
Source: Neurological Sciences. Dec2014, Vol. 35 Issue 12, p1947-1953. 7p. 3 Diagrams, 4 Charts.
Subjects: Vitamin D receptors, Genetic polymorphisms, Disease susceptibility, Parkinson's disease, Alzheimer's disease, Meta-analysis
Abstract: The goal of this study was to examine whether vitamin D receptor (VDR) polymorphisms are associated with susceptibility to Parkinson's disease (PD) and Alzheimer's disease (AD). A meta-analysis was performed to investigate the association between VDR FokI, BsmI, TaqI, ApaI, rs4334089, or rs11568820 polymorphism and susceptibility to PD or AD. Thirteen studies, including seven on PD and six on AD, were included in this meta-analysis. The meta-analysis revealed an association between the BB + Bb genotype and PD in the Asian population (OR 0.478, 95 % CI 0.259-0.884, p = 0.018). We also observed a significant association between PD and the FokI F allele (OR 1.413, 95 % CI 1.144-1.746, p = 0.001). Meta-analysis of the A allele, the AA vs. Aa + aa, and the AA vs. aa for the ApaI polymorphism revealed significant associations with AD (OR 0.729, 95 % CI 0.0.591-0.900, p = 0.034; OR 0.591, 95 % CI 0.431-0.810, p = 0.001; OR 0.580, 95 % CI 0.361-0.931, p = 0.024, respectively). This meta-analysis demonstrates that the VDR BsmI polymorphism is associated with PD susceptibility in Asians, and the FokI polymorphism is associated with PD. Furthermore, we identified associations between the VDR TaqI and ApaI polymorphisms and AD susceptibility. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Vitamin D receptor polymorphisms and susceptibility to Parkinson's disease and Alzheimer's disease: a meta-analysis.
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  Data: <searchLink fieldCode="AR" term="%22Lee%2C+Young%22">Lee, Young</searchLink><br /><searchLink fieldCode="AR" term="%22Kim%2C+Jae-Hoon%22">Kim, Jae-Hoon</searchLink><br /><searchLink fieldCode="AR" term="%22Song%2C+Gwan%22">Song, Gwan</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Dec2014, Vol. 35 Issue 12, p1947-1953. 7p. 3 Diagrams, 4 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Vitamin+D+receptors%22">Vitamin D receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+polymorphisms%22">Genetic polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+susceptibility%22">Disease susceptibility</searchLink><br /><searchLink fieldCode="DE" term="%22Parkinson's+disease%22">Parkinson's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Alzheimer's+disease%22">Alzheimer's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Meta-analysis%22">Meta-analysis</searchLink>
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  Data: The goal of this study was to examine whether vitamin D receptor (VDR) polymorphisms are associated with susceptibility to Parkinson's disease (PD) and Alzheimer's disease (AD). A meta-analysis was performed to investigate the association between VDR FokI, BsmI, TaqI, ApaI, rs4334089, or rs11568820 polymorphism and susceptibility to PD or AD. Thirteen studies, including seven on PD and six on AD, were included in this meta-analysis. The meta-analysis revealed an association between the BB + Bb genotype and PD in the Asian population (OR 0.478, 95 % CI 0.259-0.884, p = 0.018). We also observed a significant association between PD and the FokI F allele (OR 1.413, 95 % CI 1.144-1.746, p = 0.001). Meta-analysis of the A allele, the AA vs. Aa + aa, and the AA vs. aa for the ApaI polymorphism revealed significant associations with AD (OR 0.729, 95 % CI 0.0.591-0.900, p = 0.034; OR 0.591, 95 % CI 0.431-0.810, p = 0.001; OR 0.580, 95 % CI 0.361-0.931, p = 0.024, respectively). This meta-analysis demonstrates that the VDR BsmI polymorphism is associated with PD susceptibility in Asians, and the FokI polymorphism is associated with PD. Furthermore, we identified associations between the VDR TaqI and ApaI polymorphisms and AD susceptibility. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10072-014-1868-4
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              Text: Dec2014
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