Expression of glucocorticoid inducible genes is associated with reductions in cornu ammonis and dentate gyrus volumes in patients with major depressive disorder.
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| Title: | Expression of glucocorticoid inducible genes is associated with reductions in cornu ammonis and dentate gyrus volumes in patients with major depressive disorder. |
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| Authors: | Cicchetti, Dante, Natsuaki, Misaki N., Frodl, Thomas, Carballedo, Angela, Frey, Eva-Maria, O'Keane, Veronica, Skokauskas, Norbert, Morris, Derrek, Gill, Michael, Hughes, Martina Mary, Harkin, Andrew, Connor, Thomas |
| Source: | Development & Psychopathology. Nov2014, Vol. 26 Issue 4pt2, p1209-1217. 9p. |
| Subjects: | Gene expression, Dentate gyrus, Glucocorticoids, Hippocampus physiology, Depressed persons, Messenger RNA, People with mental illness, Physiology |
| Abstract: | Alterations of the glucocorticoid system and of hippocampal volumes have consistently been reported in patients with major depressive disorders (MDD). The aim of the present study was to investigate whether the messenger RNA (mRNA) expression of glucocorticoid inducible genes is associated with changes in the cornu ammonis (CA) and dentate gyrus subfields. Forty-three patients with MDD and 43 healthy controls were recruited and investigated with high resolution magnetic resonance imaging. Hippocampal subfields were measured using freesurfer. Measurement of whole blood mRNA expression of glucocorticoid inducible genes serum and glucocorticoid-regulated kinase 1 (SGK1), FK506 binding protein 5 (FKBP5), and glucocorticoid induced leucine zipper (GILZ) was performed. Patients with MDD had significantly smaller volumes of CA1, CA2/3, CA4/DG, and subiculum compared to healthy controls. In the regression analysis, the factor diagnosis had a significant moderating effect on the association of SGK1 and hippocampal volumes. Patients with low expression of SGK1 had significantly smaller CA2/3 and CA4/DG volumes compared to patients with high expression of SGK1 mRNA and to healthy controls with low/high expression of SGK1, respectively. Therefore, a lack of mRNA expression of glucocorticoid inducible genes in patients with MDD that seems to correspond to a blunted cortisol response is associated with smaller hippocampal CA and dentate gyrus volumes. SGK1 seems to be particularly relevant for stress-related mental disorders. [ABSTRACT FROM PUBLISHER] |
| Copyright of Development & Psychopathology is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 99632796 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Expression of glucocorticoid inducible genes is associated with reductions in cornu ammonis and dentate gyrus volumes in patients with major depressive disorder. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Cicchetti%2C+Dante%22">Cicchetti, Dante</searchLink><br /><searchLink fieldCode="AR" term="%22Natsuaki%2C+Misaki+N%2E%22">Natsuaki, Misaki N.</searchLink><br /><searchLink fieldCode="AR" term="%22Frodl%2C+Thomas%22">Frodl, Thomas</searchLink><br /><searchLink fieldCode="AR" term="%22Carballedo%2C+Angela%22">Carballedo, Angela</searchLink><br /><searchLink fieldCode="AR" term="%22Frey%2C+Eva-Maria%22">Frey, Eva-Maria</searchLink><br /><searchLink fieldCode="AR" term="%22O'Keane%2C+Veronica%22">O'Keane, Veronica</searchLink><br /><searchLink fieldCode="AR" term="%22Skokauskas%2C+Norbert%22">Skokauskas, Norbert</searchLink><br /><searchLink fieldCode="AR" term="%22Morris%2C+Derrek%22">Morris, Derrek</searchLink><br /><searchLink fieldCode="AR" term="%22Gill%2C+Michael%22">Gill, Michael</searchLink><br /><searchLink fieldCode="AR" term="%22Hughes%2C+Martina+Mary%22">Hughes, Martina Mary</searchLink><br /><searchLink fieldCode="AR" term="%22Harkin%2C+Andrew%22">Harkin, Andrew</searchLink><br /><searchLink fieldCode="AR" term="%22Connor%2C+Thomas%22">Connor, Thomas</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Development+%26+Psychopathology%22">Development & Psychopathology</searchLink>. Nov2014, Vol. 26 Issue 4pt2, p1209-1217. 9p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Gene+expression%22">Gene expression</searchLink><br /><searchLink fieldCode="DE" term="%22Dentate+gyrus%22">Dentate gyrus</searchLink><br /><searchLink fieldCode="DE" term="%22Glucocorticoids%22">Glucocorticoids</searchLink><br /><searchLink fieldCode="DE" term="%22Hippocampus+physiology%22">Hippocampus physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Depressed+persons%22">Depressed persons</searchLink><br /><searchLink fieldCode="DE" term="%22Messenger+RNA%22">Messenger RNA</searchLink><br /><searchLink fieldCode="DE" term="%22People+with+mental+illness%22">People with mental illness</searchLink><br /><searchLink fieldCode="DE" term="%22Physiology%22">Physiology</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Alterations of the glucocorticoid system and of hippocampal volumes have consistently been reported in patients with major depressive disorders (MDD). The aim of the present study was to investigate whether the messenger RNA (mRNA) expression of glucocorticoid inducible genes is associated with changes in the cornu ammonis (CA) and dentate gyrus subfields. Forty-three patients with MDD and 43 healthy controls were recruited and investigated with high resolution magnetic resonance imaging. Hippocampal subfields were measured using freesurfer. Measurement of whole blood mRNA expression of glucocorticoid inducible genes serum and glucocorticoid-regulated kinase 1 (SGK1), FK506 binding protein 5 (FKBP5), and glucocorticoid induced leucine zipper (GILZ) was performed. Patients with MDD had significantly smaller volumes of CA1, CA2/3, CA4/DG, and subiculum compared to healthy controls. In the regression analysis, the factor diagnosis had a significant moderating effect on the association of SGK1 and hippocampal volumes. Patients with low expression of SGK1 had significantly smaller CA2/3 and CA4/DG volumes compared to patients with high expression of SGK1 mRNA and to healthy controls with low/high expression of SGK1, respectively. Therefore, a lack of mRNA expression of glucocorticoid inducible genes in patients with MDD that seems to correspond to a blunted cortisol response is associated with smaller hippocampal CA and dentate gyrus volumes. SGK1 seems to be particularly relevant for stress-related mental disorders. [ABSTRACT FROM PUBLISHER] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Development & Psychopathology is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1017/S0954579414000972 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 1209 Subjects: – SubjectFull: Gene expression Type: general – SubjectFull: Dentate gyrus Type: general – SubjectFull: Glucocorticoids Type: general – SubjectFull: Hippocampus physiology Type: general – SubjectFull: Depressed persons Type: general – SubjectFull: Messenger RNA Type: general – SubjectFull: People with mental illness Type: general – SubjectFull: Physiology Type: general Titles: – TitleFull: Expression of glucocorticoid inducible genes is associated with reductions in cornu ammonis and dentate gyrus volumes in patients with major depressive disorder. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Cicchetti, Dante – PersonEntity: Name: NameFull: Natsuaki, Misaki N. – PersonEntity: Name: NameFull: Frodl, Thomas – PersonEntity: Name: NameFull: Carballedo, Angela – PersonEntity: Name: NameFull: Frey, Eva-Maria – PersonEntity: Name: NameFull: O'Keane, Veronica – PersonEntity: Name: NameFull: Skokauskas, Norbert – PersonEntity: Name: NameFull: Morris, Derrek – PersonEntity: Name: NameFull: Gill, Michael – PersonEntity: Name: NameFull: Hughes, Martina Mary – PersonEntity: Name: NameFull: Harkin, Andrew – PersonEntity: Name: NameFull: Connor, Thomas IsPartOfRelationships: – BibEntity: Dates: – D: 02 M: 11 Text: Nov2014 Type: published Y: 2014 Identifiers: – Type: issn-print Value: 09545794 Numbering: – Type: volume Value: 26 – Type: issue Value: 4pt2 Titles: – TitleFull: Development & Psychopathology Type: main |
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