View in EDS HTML Full Text PDF Full Text

Derivation of Oocytes from Mouse Embryonic Stem Cells.

Saved in:
Bibliographic Details
Title: Derivation of Oocytes from Mouse Embryonic Stem Cells.
Authors: Hübner, Karin, Fuhrmann, Guy, Christenson, Lane K., Kehler, James, Reinbold, Rolland, De La Fuente, Rabindranath, Wood, Jennifer, Strauss III, Jerome F., Boiani, Michele, Schöler, Hans R.
Source: Science (pre-March 2025). 5/23/2003, Vol. 300 Issue 5623, p1251-1256. 6p. 5 Color Photographs, 1 Diagram.
Subjects: Germ cells, Fertility, Cell culture, Stem cells, Meiosis, Reproduction
Abstract: Continuation of mammalian species requires the formation and development of the sexually dimorphic germ cells. Cultured embryonic stem cells are generally considered pluripotent rather than totipotent because of the failure to detect germline cells under differentiating conditions. Here we show that mouse embryonic stem cells in culture can develop into oogonia that enter meiosis, recruit adjacent cells to form follicle-like structures, and later develop into blastocysts. Oogenesis in culture should contribute to various areas, including nuclear transfer and manipulation of the germ line, and advance studies on fertility treatment and germ and somatic cell interaction and differentiation. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 9971197
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Derivation of Oocytes from Mouse Embryonic Stem Cells.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Hübner%2C+Karin%22">Hübner, Karin</searchLink><br /><searchLink fieldCode="AR" term="%22Fuhrmann%2C+Guy%22">Fuhrmann, Guy</searchLink><br /><searchLink fieldCode="AR" term="%22Christenson%2C+Lane+K%2E%22">Christenson, Lane K.</searchLink><br /><searchLink fieldCode="AR" term="%22Kehler%2C+James%22">Kehler, James</searchLink><br /><searchLink fieldCode="AR" term="%22Reinbold%2C+Rolland%22">Reinbold, Rolland</searchLink><br /><searchLink fieldCode="AR" term="%22De+La+Fuente%2C+Rabindranath%22">De La Fuente, Rabindranath</searchLink><br /><searchLink fieldCode="AR" term="%22Wood%2C+Jennifer%22">Wood, Jennifer</searchLink><br /><searchLink fieldCode="AR" term="%22Strauss+III%2C+Jerome+F%2E%22">Strauss III, Jerome F.</searchLink><br /><searchLink fieldCode="AR" term="%22Boiani%2C+Michele%22">Boiani, Michele</searchLink><br /><searchLink fieldCode="AR" term="%22Schöler%2C+Hans+R%2E%22">Schöler, Hans R.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 5/23/2003, Vol. 300 Issue 5623, p1251-1256. 6p. 5 Color Photographs, 1 Diagram.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Germ+cells%22">Germ cells</searchLink><br /><searchLink fieldCode="DE" term="%22Fertility%22">Fertility</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+culture%22">Cell culture</searchLink><br /><searchLink fieldCode="DE" term="%22Stem+cells%22">Stem cells</searchLink><br /><searchLink fieldCode="DE" term="%22Meiosis%22">Meiosis</searchLink><br /><searchLink fieldCode="DE" term="%22Reproduction%22">Reproduction</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Continuation of mammalian species requires the formation and development of the sexually dimorphic germ cells. Cultured embryonic stem cells are generally considered pluripotent rather than totipotent because of the failure to detect germline cells under differentiating conditions. Here we show that mouse embryonic stem cells in culture can develop into oogonia that enter meiosis, recruit adjacent cells to form follicle-like structures, and later develop into blastocysts. Oogenesis in culture should contribute to various areas, including nuclear transfer and manipulation of the germ line, and advance studies on fertility treatment and germ and somatic cell interaction and differentiation. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=9971197
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1126/science.1083452
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 6
        StartPage: 1251
    Subjects:
      – SubjectFull: Germ cells
        Type: general
      – SubjectFull: Fertility
        Type: general
      – SubjectFull: Cell culture
        Type: general
      – SubjectFull: Stem cells
        Type: general
      – SubjectFull: Meiosis
        Type: general
      – SubjectFull: Reproduction
        Type: general
    Titles:
      – TitleFull: Derivation of Oocytes from Mouse Embryonic Stem Cells.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Hübner, Karin
      – PersonEntity:
          Name:
            NameFull: Fuhrmann, Guy
      – PersonEntity:
          Name:
            NameFull: Christenson, Lane K.
      – PersonEntity:
          Name:
            NameFull: Kehler, James
      – PersonEntity:
          Name:
            NameFull: Reinbold, Rolland
      – PersonEntity:
          Name:
            NameFull: De La Fuente, Rabindranath
      – PersonEntity:
          Name:
            NameFull: Wood, Jennifer
      – PersonEntity:
          Name:
            NameFull: Strauss III, Jerome F.
      – PersonEntity:
          Name:
            NameFull: Boiani, Michele
      – PersonEntity:
          Name:
            NameFull: Schöler, Hans R.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 23
              M: 05
              Text: 5/23/2003
              Type: published
              Y: 2003
          Identifiers:
            – Type: issn-print
              Value: 00368075
          Numbering:
            – Type: volume
              Value: 300
            – Type: issue
              Value: 5623
          Titles:
            – TitleFull: Science (pre-March 2025)
              Type: main
ResultId 1