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Serum 25-hydroxyvitamin D and cognitive decline in the very old: the Newcastle 85+ Study.

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Title: Serum 25-hydroxyvitamin D and cognitive decline in the very old: the Newcastle 85+ Study.
Authors: Granic, A., Hill, T. R., Kirkwood, T. B. L., Davies, K., Collerton, J., Martin ‐ Ruiz, C., Zglinicki, T., Saxby, B. K., Wesnes, K. A., Collerton, D., Mathers, J. C., Jagger, C.
Source: European Journal of Neurology. Jan2015, Vol. 22 Issue 1, p106-106. 11p. 4 Charts.
Subjects: Cognition disorders treatment, Reaction time, Confidence intervals, Mental health, Serum
Abstract: Background and purpose Studies investigating the association between 25-hydroxyvitamin D [25( OH) D] and cognition in the very old (85+) are lacking. Methods Cross-sectional (baseline) and prospective data (up to 3 years follow-up) from 775 participants in the Newcastle 85+ Study were analysed for global (measured by the Standardized Mini- Mental State Examination) and attention-specific (measured by the attention battery of the Cognitive Drug Research test) cognitive performance in relation to season-specific 25( OH) D quartiles. Results Those in the lowest and highest season-specific 25( OH) D quartiles had an increased risk of impaired prevalent (1.66, 95% confidence interval 1.06-2.60, P = 0.03; 1.62, 95% confidence interval 1.02-2.59, P = 0.04, respectively) but not incident global cognitive functioning or decline in functioning compared with those in the middle quartiles adjusted for sociodemographic, health and lifestyle confounders. Random effects models showed that participants belonging to the lowest and highest 25( OH) D quartiles, compared with those in the middle quartiles, had overall slower (log-transformed) attention reaction times for Choice Reaction Time (lowest, β = 0.023, P = 0.01; highest, β = 0.021, P = 0.02), Digit Vigilance Task (lowest, β = 0.009, P = 0.05; highest, β = 0.01, P = 0.02) and Power of Attention (lowest, β = 0.017, P = 0.02; highest, β = 0.022, P = 0.002) and greater Reaction Time Variability (lowest, β = 0.021, P = 0.02; highest, β = 0.02, P = 0.03). The increased risk of worse global cognition and attention amongst those in the highest quartile was not observed in non-users of vitamin D supplements/medication. Conclusion Low and high season-specific 25( OH) D quartiles were associated with prevalent cognitive impairment and poorer overall performance in attention-specific tasks over 3 years in the very old, but not with global cognitive decline or incident impairment. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Serum 25-hydroxyvitamin D and cognitive decline in the very old: the Newcastle 85+ Study.
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  Data: <searchLink fieldCode="AR" term="%22Granic%2C+A%2E%22">Granic, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Hill%2C+T%2E+R%2E%22">Hill, T. R.</searchLink><br /><searchLink fieldCode="AR" term="%22Kirkwood%2C+T%2E+B%2E+L%2E%22">Kirkwood, T. B. L.</searchLink><br /><searchLink fieldCode="AR" term="%22Davies%2C+K%2E%22">Davies, K.</searchLink><br /><searchLink fieldCode="AR" term="%22Collerton%2C+J%2E%22">Collerton, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Martin+‐+Ruiz%2C+C%2E%22">Martin ‐ Ruiz, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Zglinicki%2C+T%2E%22">Zglinicki, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Saxby%2C+B%2E+K%2E%22">Saxby, B. K.</searchLink><br /><searchLink fieldCode="AR" term="%22Wesnes%2C+K%2E+A%2E%22">Wesnes, K. A.</searchLink><br /><searchLink fieldCode="AR" term="%22Collerton%2C+D%2E%22">Collerton, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Mathers%2C+J%2E+C%2E%22">Mathers, J. C.</searchLink><br /><searchLink fieldCode="AR" term="%22Jagger%2C+C%2E%22">Jagger, C.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Jan2015, Vol. 22 Issue 1, p106-106. 11p. 4 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Cognition+disorders+treatment%22">Cognition disorders treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Reaction+time%22">Reaction time</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+health%22">Mental health</searchLink><br /><searchLink fieldCode="DE" term="%22Serum%22">Serum</searchLink>
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  Label: Abstract
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  Data: Background and purpose Studies investigating the association between 25-hydroxyvitamin D [25( OH) D] and cognition in the very old (85+) are lacking. Methods Cross-sectional (baseline) and prospective data (up to 3 years follow-up) from 775 participants in the Newcastle 85+ Study were analysed for global (measured by the Standardized Mini- Mental State Examination) and attention-specific (measured by the attention battery of the Cognitive Drug Research test) cognitive performance in relation to season-specific 25( OH) D quartiles. Results Those in the lowest and highest season-specific 25( OH) D quartiles had an increased risk of impaired prevalent (1.66, 95% confidence interval 1.06-2.60, P = 0.03; 1.62, 95% confidence interval 1.02-2.59, P = 0.04, respectively) but not incident global cognitive functioning or decline in functioning compared with those in the middle quartiles adjusted for sociodemographic, health and lifestyle confounders. Random effects models showed that participants belonging to the lowest and highest 25( OH) D quartiles, compared with those in the middle quartiles, had overall slower (log-transformed) attention reaction times for Choice Reaction Time (lowest, β = 0.023, P = 0.01; highest, β = 0.021, P = 0.02), Digit Vigilance Task (lowest, β = 0.009, P = 0.05; highest, β = 0.01, P = 0.02) and Power of Attention (lowest, β = 0.017, P = 0.02; highest, β = 0.022, P = 0.002) and greater Reaction Time Variability (lowest, β = 0.021, P = 0.02; highest, β = 0.02, P = 0.03). The increased risk of worse global cognition and attention amongst those in the highest quartile was not observed in non-users of vitamin D supplements/medication. Conclusion Low and high season-specific 25( OH) D quartiles were associated with prevalent cognitive impairment and poorer overall performance in attention-specific tasks over 3 years in the very old, but not with global cognitive decline or incident impairment. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/ene.12539
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      – SubjectFull: Confidence intervals
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