Research. Associations of Plasma Concentrations of Dichlorodiphenyldichloroethylene and Polychlorinated Biphenyls with Prostate Cancer: A Case–Control Study in Guadeloupe (French West Indies).
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| Title: | Research. Associations of Plasma Concentrations of Dichlorodiphenyldichloroethylene and Polychlorinated Biphenyls with Prostate Cancer: A Case–Control Study in Guadeloupe (French West Indies). |
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| Authors: | Emeville, Elise1,2, Giusti, Arnaud3, Coumoul, Xavier4,5, Thomé, Jean-Pierre3, Blanchet, Pascal1,6, Multigner, Luc1 luc.multigner@inserm.fr |
| Source: | Environmental Health Perspectives. Apr2015, Vol. 123 Issue 4, p317-323. 7p. 4 Charts. |
| Subject Terms: | *Insecticides, *Polychlorinated biphenyls, Confidence intervals, Prostate tumors, Research funding, Logistic regression analysis, Data analysis software, Descriptive statistics, Odds ratio, Tumor risk factors |
| Abstract: | BACKGROUND: Long-term exposure to persistent pollutants with hormonal properties (endocrine- disrupting chemicals; EDCs) may contribute to the risk of prostate cancer (PCa). However, epidemiological evidence remains limited. OBJECTIVES: We investigated the relationship between PCa and plasma concentrations of universally widespread pollutants, in particular p,p '-dichlorodiphenyl dichloroethene (DDE) and the non-dioxin-like polychlorinated biphenyl congener 153 (PCB-153). METHODS: We evaluated 576 men with newly diagnosed PCa (before treatment) and 655 controls in Guadeloupe (French West Indies). Exposure was analyzed according to case -- control status. Associations were assessed by unconditional logistic regression analysis, controlling for confounding factors. Missing data were handled by multiple imputation. RESULTS: We estimated a significant positive association between DDE and PCa [adjusted odds ratio (OR) = 1.53; 95% CI: 1.02, 2.30 for the highest vs. lowest quintile of exposure; ptrend = 0.01]. PCB-153 was inversely associated with PCa (OR = 0.30; 95% CI: 0.19, 0.47 for the highest vs. lowest quintile of exposure values; ptrend < 0.001). Also, PCB-153 was more strongly associated with low-grade than with high-grade PCa. CONCLUSIONS: Associations of PCa with DDE and PCB-153 were in opposite directions. This may reflect differences in the mechanisms of action of these EDCs; and although our findings need to be replicated in other populations, they are consistent with complex effects of EDCs on human health. CITATION: Emeville E, Giusti A, Coumoul X, Thome JP, Blanchet P, Multigner L. 2015. Associations of plasma concentrations of dichlorodiphenyldichloroethylene and polychlorinated biphenyls with prostate cancer: a case -- control study in Guadeloupe (French West Indies). Environ Health Perspect 123:317-323; http://dx.doi.org/10.1289/ehp.1408407 [ABSTRACT FROM AUTHOR] |
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| Abstract: | BACKGROUND: Long-term exposure to persistent pollutants with hormonal properties (endocrine- disrupting chemicals; EDCs) may contribute to the risk of prostate cancer (PCa). However, epidemiological evidence remains limited. OBJECTIVES: We investigated the relationship between PCa and plasma concentrations of universally widespread pollutants, in particular p,p '-dichlorodiphenyl dichloroethene (DDE) and the non-dioxin-like polychlorinated biphenyl congener 153 (PCB-153). METHODS: We evaluated 576 men with newly diagnosed PCa (before treatment) and 655 controls in Guadeloupe (French West Indies). Exposure was analyzed according to case -- control status. Associations were assessed by unconditional logistic regression analysis, controlling for confounding factors. Missing data were handled by multiple imputation. RESULTS: We estimated a significant positive association between DDE and PCa [adjusted odds ratio (OR) = 1.53; 95% CI: 1.02, 2.30 for the highest vs. lowest quintile of exposure; ptrend = 0.01]. PCB-153 was inversely associated with PCa (OR = 0.30; 95% CI: 0.19, 0.47 for the highest vs. lowest quintile of exposure values; ptrend < 0.001). Also, PCB-153 was more strongly associated with low-grade than with high-grade PCa. CONCLUSIONS: Associations of PCa with DDE and PCB-153 were in opposite directions. This may reflect differences in the mechanisms of action of these EDCs; and although our findings need to be replicated in other populations, they are consistent with complex effects of EDCs on human health. CITATION: Emeville E, Giusti A, Coumoul X, Thome JP, Blanchet P, Multigner L. 2015. Associations of plasma concentrations of dichlorodiphenyldichloroethylene and polychlorinated biphenyls with prostate cancer: a case -- control study in Guadeloupe (French West Indies). Environ Health Perspect 123:317-323; http://dx.doi.org/10.1289/ehp.1408407 [ABSTRACT FROM AUTHOR] |
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| ISSN: | 00916765 |
| DOI: | 10.1289/ehp.1408407 |
