First-Trimester Urinary Bisphenol A Concentration in Relation to Anogenital Distance, an Androgen-Sensitive Measure of Reproductive Development, in Infant Girls.
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| Title: | First-Trimester Urinary Bisphenol A Concentration in Relation to Anogenital Distance, an Androgen-Sensitive Measure of Reproductive Development, in Infant Girls. |
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| Authors: | Barrett, Emily S.1,2 Emily.barrett@eohsi.rutgers.edu, Sathyanarayana, Sheela3,4, Mbowe, Omar5, Thurston, Sally W.5, Redmon, J. Bruce6, Nguyen, Ruby H. N.7, Swan, Shanna H.8 |
| Source: | Environmental Health Perspectives. Jul2017, Vol. 125 Issue 7, p1-8. 8p. 1 Diagram, 2 Charts. |
| Subject Terms: | *Plastics, Anus, Female reproductive organs, Anthropometry, Hormone antagonists, Human reproduction, Longitudinal method, Polymethylmethacrylate, First trimester of pregnancy, Research funding, Statistics, Anatomy |
| Abstract: | INTRODUCTION: Evidence from animal models suggests that prenatal exposure to bisphenol A (BPA), a ubiquitous endocrine-disrupting chemical, is associated with adverse reproductive outcomes in females. Exposure during early gestation, a critical period for reproductive development, is of particular concern. Anogenital distance (AGD) is a sensitive biomarker of the fetal hormonal milieu and a measure of reproductive toxicity in animal models. In some studies, the daughters of BPA-exposed dams have shorter AGD than controls. Here, we investigate this relationship in humans. METHODS: BPA was assayed in first-trimester urine samples from 385 participants who delivered infant girls in a multicenter pregnancy cohort study. After birth, daughters underwent exams that included two measures of AGD (AGD-AC: distance from center of anus to clitoris; AGD-AF: distance from center of anus to fourchette). We fit linear regression models to examine the association between specific gravity-adjusted (SPG-adj) maternal BPA concentrations and infant AGD, adjusting for covariates. RESULTS: BPA was detectable in 94% of women. In covariate-adjusted models fit on 381 eligible subjects, the natural logarithm of SpG-adj maternal BPA concentration was inversely associated with infant AGD-AC [β= -0:56, 95% confidence interval (CI): -0:97, -0:15]. We observed no association between maternal BPA and infant AGD-AF. CONCLUSION: BPA may have toxic effects on the female reproductive system in humans, as it does in animal models. Higher first-trimester BPA exposure was associated with significantly shorter AGD in daughters, suggesting that BPA may alter the hormonal environment of the female fetus. [ABSTRACT FROM AUTHOR] |
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| Abstract: | INTRODUCTION: Evidence from animal models suggests that prenatal exposure to bisphenol A (BPA), a ubiquitous endocrine-disrupting chemical, is associated with adverse reproductive outcomes in females. Exposure during early gestation, a critical period for reproductive development, is of particular concern. Anogenital distance (AGD) is a sensitive biomarker of the fetal hormonal milieu and a measure of reproductive toxicity in animal models. In some studies, the daughters of BPA-exposed dams have shorter AGD than controls. Here, we investigate this relationship in humans. METHODS: BPA was assayed in first-trimester urine samples from 385 participants who delivered infant girls in a multicenter pregnancy cohort study. After birth, daughters underwent exams that included two measures of AGD (AGD-AC: distance from center of anus to clitoris; AGD-AF: distance from center of anus to fourchette). We fit linear regression models to examine the association between specific gravity-adjusted (SPG-adj) maternal BPA concentrations and infant AGD, adjusting for covariates. RESULTS: BPA was detectable in 94% of women. In covariate-adjusted models fit on 381 eligible subjects, the natural logarithm of SpG-adj maternal BPA concentration was inversely associated with infant AGD-AC [β= -0:56, 95% confidence interval (CI): -0:97, -0:15]. We observed no association between maternal BPA and infant AGD-AF. CONCLUSION: BPA may have toxic effects on the female reproductive system in humans, as it does in animal models. Higher first-trimester BPA exposure was associated with significantly shorter AGD in daughters, suggesting that BPA may alter the hormonal environment of the female fetus. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 00916765 |
| DOI: | 10.1289/EHP875 |
