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β-glucuronidase as a biomarker for assessing the exposure to anticholinergic pesticides: A meta-analysis.

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Bibliographic Details
Title: β-glucuronidase as a biomarker for assessing the exposure to anticholinergic pesticides: A meta-analysis.
Authors: Serafín-Fabian, Jesús Isimar1 (AUTHOR), Elena Moreno-Godínez, Ma.2 (AUTHOR), Flores-Alfaro, Eugenia1 (AUTHOR), Parra-Rojas, Isela3 (AUTHOR), Rojas-García, Aurora Elizabeth4 (AUTHOR), Campos-Viguri, Gabriela Elizabeth5 (AUTHOR), Cahua-Pablo, José Ángel1 (AUTHOR), Ramírez-Vargas, Marco Antonio1,2 (AUTHOR) marvar@uagro.mx
Source: Environmental Toxicology & Pharmacology. Oct2023, Vol. 103, pN.PAG-N.PAG. 1p.
Subject Terms: *Pesticides, *Biomarkers, *Biological monitoring, Parasympatholytic agents, Sequential analysis, Poisoning, Occupational exposure
Abstract: The human exposure to anticholinergic pesticides has been associated with the development of various diseases. Therefore, several biomarkers have been proposed for biomonitoring human exposure to anticholinergic pesticides. This work evaluated the effect of human exposure to anticholinergic pesticides on β-glucuronidase (GUSB) levels. A systematic review was performed using PubMed, Web of Science, Scopus, and EBSCO databases up to December 2021. The statistical analysis employed standardized mean differences and meta-regression. And the trial sequential analysis was performed. Nine studies were included. A monotonic relationship was observed between poisoning severity and GUSB. Furthermore, BuChE levels were correlated with GUSB levels. The results indicated that GUSB levels could be used as a possible diagnosis biomarker in poisoning related to anticholinergic pesticide exposure. However, the use of GUSB to assess the chronic exposure to anticholinergic pesticides could be only performed in recent exposure (≈ 7 days after last exposure). [ABSTRACT FROM AUTHOR]
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Database: GreenFILE
Description
Abstract:The human exposure to anticholinergic pesticides has been associated with the development of various diseases. Therefore, several biomarkers have been proposed for biomonitoring human exposure to anticholinergic pesticides. This work evaluated the effect of human exposure to anticholinergic pesticides on β-glucuronidase (GUSB) levels. A systematic review was performed using PubMed, Web of Science, Scopus, and EBSCO databases up to December 2021. The statistical analysis employed standardized mean differences and meta-regression. And the trial sequential analysis was performed. Nine studies were included. A monotonic relationship was observed between poisoning severity and GUSB. Furthermore, BuChE levels were correlated with GUSB levels. The results indicated that GUSB levels could be used as a possible diagnosis biomarker in poisoning related to anticholinergic pesticide exposure. However, the use of GUSB to assess the chronic exposure to anticholinergic pesticides could be only performed in recent exposure (≈ 7 days after last exposure). [ABSTRACT FROM AUTHOR]
ISSN:13826689
DOI:10.1016/j.etap.2023.104279