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Low concentrations of cyantraniliprole negatively affects the development of Spodoptera frugiperda by disruption of ecdysteroid biosynthesis and carbohydrate and lipid metabolism.

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Title:	Low concentrations of cyantraniliprole negatively affects the development of Spodoptera frugiperda by disruption of ecdysteroid biosynthesis and carbohydrate and lipid metabolism.
Authors:	Lv, Shushu¹ (AUTHOR), Guan, Daojie¹ (AUTHOR), Wei, Jiaping¹ (AUTHOR), Ge, Huichen¹ (AUTHOR), Zhou, Xiaoyang¹ (AUTHOR), Zheng, Yang¹ (AUTHOR), Qian, Kun¹ (AUTHOR), Wang, Jianjun^1,2 (AUTHOR) wangjj@yzu.edu.cn
Source:	Pesticide Biochemistry & Physiology. Mar2024, Vol. 200, pN.PAG-N.PAG. 1p.
Subject Terms:	*Biosynthesis, Fall armyworm, Carbohydrate metabolism, Lipid metabolism, Trehalose, Life history theory, Reproduction, Hatchability of eggs
Abstract:	In addition to the acute lethal toxicity, insecticides might affect population dynamics of insect pests by inducing life history trait changes under low concentrations, however, the underlying mechanisms remain not well understood. Here we examined systemic impacts on development and reproduction caused by low concentration exposures to cyantraniliprole in the fall armyworm (FAW), Spodoptera frugiperda, and the putative underlying mechanisms were investigated. The results showed that exposure of third-instar larvae to LC 10 and LC 30 of cyantraniliprole significantly extended larvae duration by 1.46 and 5.41 days, respectively. Treatment with LC 30 of cyantraniliprole significantly decreased the pupae weight and pupation rate as well as the longevity, fecundity and egg hatchability of female adults. Consistently, we found that exposure of FAW to LC 30 cyantraniliprole downregulated the mRNA expression of four ecdysteroid biosynthesis genes including SfNobo , SfShd , SfSpo and SfDib and one ecdysone response gene SfE75 in the larvae as well as the gene encoding vitellogenin (SfVg) in the female adults. We also found that treatment with LC 30 of cyantraniliprole significantly decreased the whole body levels of glucose, trehalose, glycogen and triglyceride in the larvae. Our results indicate that low concentration of cyantraniliprole inhibited FAW development by disruption of ecdysteroid biosynthesis as well as carbohydrate and lipid metabolism, which have applied implications for the control of FAW. [Display omitted] • Low concentrations of cyantraniliprole negatively affected the fitness of S. frugiperda. • LC 30 cyantraniliprole downregulated the mRNA expression of ecdysteroid biosynthesis genes. • LC 30 cyantraniliprole treatment led to disruption of carbohydrate and lipid metabolism. [ABSTRACT FROM AUTHOR]
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Database:	GreenFILE

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Abstract:	In addition to the acute lethal toxicity, insecticides might affect population dynamics of insect pests by inducing life history trait changes under low concentrations, however, the underlying mechanisms remain not well understood. Here we examined systemic impacts on development and reproduction caused by low concentration exposures to cyantraniliprole in the fall armyworm (FAW), Spodoptera frugiperda, and the putative underlying mechanisms were investigated. The results showed that exposure of third-instar larvae to LC 10 and LC 30 of cyantraniliprole significantly extended larvae duration by 1.46 and 5.41 days, respectively. Treatment with LC 30 of cyantraniliprole significantly decreased the pupae weight and pupation rate as well as the longevity, fecundity and egg hatchability of female adults. Consistently, we found that exposure of FAW to LC 30 cyantraniliprole downregulated the mRNA expression of four ecdysteroid biosynthesis genes including SfNobo , SfShd , SfSpo and SfDib and one ecdysone response gene SfE75 in the larvae as well as the gene encoding vitellogenin (SfVg) in the female adults. We also found that treatment with LC 30 of cyantraniliprole significantly decreased the whole body levels of glucose, trehalose, glycogen and triglyceride in the larvae. Our results indicate that low concentration of cyantraniliprole inhibited FAW development by disruption of ecdysteroid biosynthesis as well as carbohydrate and lipid metabolism, which have applied implications for the control of FAW. [Display omitted] • Low concentrations of cyantraniliprole negatively affected the fitness of S. frugiperda. • LC 30 cyantraniliprole downregulated the mRNA expression of ecdysteroid biosynthesis genes. • LC 30 cyantraniliprole treatment led to disruption of carbohydrate and lipid metabolism. [ABSTRACT FROM AUTHOR]
ISSN:	00483575
DOI:	10.1016/j.pestbp.2024.105827