Response to "Comment on 'IARC Workshop on the Key Characteristics of Carcinogens: Assessment of End Points for Evaluating Mechanistic Evidence of Carcinogenic Hazards'".
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| Title: | Response to "Comment on 'IARC Workshop on the Key Characteristics of Carcinogens: Assessment of End Points for Evaluating Mechanistic Evidence of Carcinogenic Hazards'". |
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| Authors: | DeMarini, David M., Chiu, Weihsueh A.1, Guyton, Kathryn Z.2, Gwinn, William3, Reisfeld, Brad3, Wang, Amy, de Conti, Aline4, Schubauer-Berigan, Mary K.4, Madia, Federica4 madiaf@iarc.who.int |
| Source: | Environmental Health Perspectives. May2026, Vol. 134 Issue 1, p5-7. 3p. |
| Subject Terms: | *Environmental health, *Mutagenicity testing, *Carcinogens, *Pollutants, *Environmental exposure, *Hazardous substances, *Public health, Tumor risk factors, Risk assessment, Consensus (Social sciences), Serial publications, Data analysis, Human research subjects, Oxidative stress, Adult education workshops, Conceptual structures, Research methodology, Statistics |
| Abstract: | The article focuses on clarifying the role of the key characteristics (KCs) framework in evaluating carcinogenic mechanisms within the International Agency for Research on Cancer (IARC) Monographs. The KCs framework, developed from a review of established human carcinogens, provides a systematic and transparent method to assess mechanistic evidence without bias toward specific mechanisms. It emphasizes that individual KCs, such as "induces oxidative stress" or "is genotoxic," should not be used alone to establish strong mechanistic evidence or to classify agents as probable human carcinogens (Group 2A), but rather in combination with other evidence streams. The article also highlights that the KCs approach is increasingly applied by agencies like the US Environmental Protection Agency and the US National Toxicology Program to support cancer hazard identification and risk assessment. [Extracted from the article] |
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| Database: | GreenFILE |
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| Abstract: | The article focuses on clarifying the role of the key characteristics (KCs) framework in evaluating carcinogenic mechanisms within the International Agency for Research on Cancer (IARC) Monographs. The KCs framework, developed from a review of established human carcinogens, provides a systematic and transparent method to assess mechanistic evidence without bias toward specific mechanisms. It emphasizes that individual KCs, such as "induces oxidative stress" or "is genotoxic," should not be used alone to establish strong mechanistic evidence or to classify agents as probable human carcinogens (Group 2A), but rather in combination with other evidence streams. The article also highlights that the KCs approach is increasingly applied by agencies like the US Environmental Protection Agency and the US National Toxicology Program to support cancer hazard identification and risk assessment. [Extracted from the article] |
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| ISSN: | 00916765 |
| DOI: | 10.1021/EHP.6c00050 |
