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Response to "Comment on 'IARC Workshop on the Key Characteristics of Carcinogens: Assessment of End Points for Evaluating Mechanistic Evidence of Carcinogenic Hazards'".

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Title: Response to "Comment on 'IARC Workshop on the Key Characteristics of Carcinogens: Assessment of End Points for Evaluating Mechanistic Evidence of Carcinogenic Hazards'".
Authors: DeMarini, David M., Chiu, Weihsueh A.1, Guyton, Kathryn Z.2, Gwinn, William3, Reisfeld, Brad3, Wang, Amy, de Conti, Aline4, Schubauer-Berigan, Mary K.4, Madia, Federica4 madiaf@iarc.who.int
Source: Environmental Health Perspectives. May2026, Vol. 134 Issue 1, p5-7. 3p.
Subject Terms: *Environmental health, *Mutagenicity testing, *Carcinogens, *Pollutants, *Environmental exposure, *Hazardous substances, *Public health, Tumor risk factors, Risk assessment, Consensus (Social sciences), Serial publications, Data analysis, Human research subjects, Oxidative stress, Adult education workshops, Conceptual structures, Research methodology, Statistics
Abstract: The article focuses on clarifying the role of the key characteristics (KCs) framework in evaluating carcinogenic mechanisms within the International Agency for Research on Cancer (IARC) Monographs. The KCs framework, developed from a review of established human carcinogens, provides a systematic and transparent method to assess mechanistic evidence without bias toward specific mechanisms. It emphasizes that individual KCs, such as "induces oxidative stress" or "is genotoxic," should not be used alone to establish strong mechanistic evidence or to classify agents as probable human carcinogens (Group 2A), but rather in combination with other evidence streams. The article also highlights that the KCs approach is increasingly applied by agencies like the US Environmental Protection Agency and the US National Toxicology Program to support cancer hazard identification and risk assessment. [Extracted from the article]
Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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Items – Name: Title
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  Data: Response to "Comment on 'IARC Workshop on the Key Characteristics of Carcinogens: Assessment of End Points for Evaluating Mechanistic Evidence of Carcinogenic Hazards'".
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22DeMarini%2C+David+M%2E%22">DeMarini, David M.</searchLink><br /><searchLink fieldCode="AR" term="%22Chiu%2C+Weihsueh+A%2E%22">Chiu, Weihsueh A.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Guyton%2C+Kathryn+Z%2E%22">Guyton, Kathryn Z.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Gwinn%2C+William%22">Gwinn, William</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Reisfeld%2C+Brad%22">Reisfeld, Brad</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Wang%2C+Amy%22">Wang, Amy</searchLink><br /><searchLink fieldCode="AR" term="%22de+Conti%2C+Aline%22">de Conti, Aline</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Schubauer-Berigan%2C+Mary+K%2E%22">Schubauer-Berigan, Mary K.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Madia%2C+Federica%22">Madia, Federica</searchLink><relatesTo>4</relatesTo><i> madiaf@iarc.who.int</i>
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  Data: <searchLink fieldCode="JN" term="%22Environmental+Health+Perspectives%22">Environmental Health Perspectives</searchLink>. May2026, Vol. 134 Issue 1, p5-7. 3p.
– Name: Subject
  Label: Subject Terms
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  Data: *<searchLink fieldCode="DE" term="%22Environmental+health%22">Environmental health</searchLink><br />*<searchLink fieldCode="DE" term="%22Mutagenicity+testing%22">Mutagenicity testing</searchLink><br />*<searchLink fieldCode="DE" term="%22Carcinogens%22">Carcinogens</searchLink><br />*<searchLink fieldCode="DE" term="%22Pollutants%22">Pollutants</searchLink><br />*<searchLink fieldCode="DE" term="%22Environmental+exposure%22">Environmental exposure</searchLink><br />*<searchLink fieldCode="DE" term="%22Hazardous+substances%22">Hazardous substances</searchLink><br />*<searchLink fieldCode="DE" term="%22Public+health%22">Public health</searchLink><br /><searchLink fieldCode="DE" term="%22Tumor+risk+factors%22">Tumor risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Risk+assessment%22">Risk assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Consensus+%28Social+sciences%29%22">Consensus (Social sciences)</searchLink><br /><searchLink fieldCode="DE" term="%22Serial+publications%22">Serial publications</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis%22">Data analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Human+research+subjects%22">Human research subjects</searchLink><br /><searchLink fieldCode="DE" term="%22Oxidative+stress%22">Oxidative stress</searchLink><br /><searchLink fieldCode="DE" term="%22Adult+education+workshops%22">Adult education workshops</searchLink><br /><searchLink fieldCode="DE" term="%22Conceptual+structures%22">Conceptual structures</searchLink><br /><searchLink fieldCode="DE" term="%22Research+methodology%22">Research methodology</searchLink><br /><searchLink fieldCode="DE" term="%22Statistics%22">Statistics</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The article focuses on clarifying the role of the key characteristics (KCs) framework in evaluating carcinogenic mechanisms within the International Agency for Research on Cancer (IARC) Monographs. The KCs framework, developed from a review of established human carcinogens, provides a systematic and transparent method to assess mechanistic evidence without bias toward specific mechanisms. It emphasizes that individual KCs, such as "induces oxidative stress" or "is genotoxic," should not be used alone to establish strong mechanistic evidence or to classify agents as probable human carcinogens (Group 2A), but rather in combination with other evidence streams. The article also highlights that the KCs approach is increasingly applied by agencies like the US Environmental Protection Agency and the US National Toxicology Program to support cancer hazard identification and risk assessment. [Extracted from the article]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1021/EHP.6c00050
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 3
        StartPage: 5
    Subjects:
      – SubjectFull: Environmental health
        Type: general
      – SubjectFull: Mutagenicity testing
        Type: general
      – SubjectFull: Carcinogens
        Type: general
      – SubjectFull: Pollutants
        Type: general
      – SubjectFull: Environmental exposure
        Type: general
      – SubjectFull: Hazardous substances
        Type: general
      – SubjectFull: Public health
        Type: general
      – SubjectFull: Tumor risk factors
        Type: general
      – SubjectFull: Risk assessment
        Type: general
      – SubjectFull: Consensus (Social sciences)
        Type: general
      – SubjectFull: Serial publications
        Type: general
      – SubjectFull: Data analysis
        Type: general
      – SubjectFull: Human research subjects
        Type: general
      – SubjectFull: Oxidative stress
        Type: general
      – SubjectFull: Adult education workshops
        Type: general
      – SubjectFull: Conceptual structures
        Type: general
      – SubjectFull: Research methodology
        Type: general
      – SubjectFull: Statistics
        Type: general
    Titles:
      – TitleFull: Response to "Comment on 'IARC Workshop on the Key Characteristics of Carcinogens: Assessment of End Points for Evaluating Mechanistic Evidence of Carcinogenic Hazards'".
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            – D: 01
              M: 05
              Text: May2026
              Type: published
              Y: 2026
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