Investigation of protein-styrene oxide adducts as a molecular biomarker of human exposed to styrene.
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| Title: | Investigation of protein-styrene oxide adducts as a molecular biomarker of human exposed to styrene. |
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| Authors: | Liu, Shu-fen, Fang, Qing-ming, Jin, Zu-liang, Rappaport, M. S. |
| Source: | Journal of Environmental Sciences (IOS Press). Oct2001, Vol. 13 Issue 4, p391. 7p. 10 Graphs. |
| Subject Terms: | *Styrene oxide, *Styrene |
| Abstract: | Abstract: Hemoglobin-styrene oxide adducts in blood have been studied as a molecular biomarker of worker exposed to styrene. Determination of protein-styrene oxide adducts in different biological samples with modified Raney-Ni procedure is described in this paper. The following biological samples have been investigated: fresh rat blood reacted with styrene oxide in vitro; rat blood reacted with styrene or styrene oxide in vivo; vein blood from workers exposed to styrene in two factories. The data showed that there was a good linear dose-response relationship between reacting dose of styrene oxide or styrene and amount of protein-styrene oxide adducts in both in vitro and in vivo experiments. For human samples, a close-response relationship between protein adducts and styrene exposure can be found in glass fiber factory, but not in piano manufacture plant. [ABSTRACT FROM AUTHOR] |
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| Database: | GreenFILE |
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| Abstract: | Abstract: Hemoglobin-styrene oxide adducts in blood have been studied as a molecular biomarker of worker exposed to styrene. Determination of protein-styrene oxide adducts in different biological samples with modified Raney-Ni procedure is described in this paper. The following biological samples have been investigated: fresh rat blood reacted with styrene oxide in vitro; rat blood reacted with styrene or styrene oxide in vivo; vein blood from workers exposed to styrene in two factories. The data showed that there was a good linear dose-response relationship between reacting dose of styrene oxide or styrene and amount of protein-styrene oxide adducts in both in vitro and in vivo experiments. For human samples, a close-response relationship between protein adducts and styrene exposure can be found in glass fiber factory, but not in piano manufacture plant. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 10010742 |
