Investigation of protein-styrene oxide adducts as a molecular biomarker of human exposed to styrene.
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| Title: | Investigation of protein-styrene oxide adducts as a molecular biomarker of human exposed to styrene. |
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| Authors: | Liu, Shu-fen, Fang, Qing-ming, Jin, Zu-liang, Rappaport, M. S. |
| Source: | Journal of Environmental Sciences (IOS Press). Oct2001, Vol. 13 Issue 4, p391. 7p. 10 Graphs. |
| Subject Terms: | *Styrene oxide, *Styrene |
| Abstract: | Abstract: Hemoglobin-styrene oxide adducts in blood have been studied as a molecular biomarker of worker exposed to styrene. Determination of protein-styrene oxide adducts in different biological samples with modified Raney-Ni procedure is described in this paper. The following biological samples have been investigated: fresh rat blood reacted with styrene oxide in vitro; rat blood reacted with styrene or styrene oxide in vivo; vein blood from workers exposed to styrene in two factories. The data showed that there was a good linear dose-response relationship between reacting dose of styrene oxide or styrene and amount of protein-styrene oxide adducts in both in vitro and in vivo experiments. For human samples, a close-response relationship between protein adducts and styrene exposure can be found in glass fiber factory, but not in piano manufacture plant. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Environmental Sciences (IOS Press) is the property of IOS Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: 8gh DbLabel: GreenFILE An: 5595688 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Investigation of protein-styrene oxide adducts as a molecular biomarker of human exposed to styrene. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Liu%2C+Shu-fen%22">Liu, Shu-fen</searchLink><br /><searchLink fieldCode="AR" term="%22Fang%2C+Qing-ming%22">Fang, Qing-ming</searchLink><br /><searchLink fieldCode="AR" term="%22Jin%2C+Zu-liang%22">Jin, Zu-liang</searchLink><br /><searchLink fieldCode="AR" term="%22Rappaport%2C+M%2E+S%2E%22">Rappaport, M. S.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Environmental+Sciences+%28IOS+Press%29%22">Journal of Environmental Sciences (IOS Press)</searchLink>. Oct2001, Vol. 13 Issue 4, p391. 7p. 10 Graphs. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22Styrene+oxide%22">Styrene oxide</searchLink><br />*<searchLink fieldCode="DE" term="%22Styrene%22">Styrene</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Abstract: Hemoglobin-styrene oxide adducts in blood have been studied as a molecular biomarker of worker exposed to styrene. Determination of protein-styrene oxide adducts in different biological samples with modified Raney-Ni procedure is described in this paper. The following biological samples have been investigated: fresh rat blood reacted with styrene oxide in vitro; rat blood reacted with styrene or styrene oxide in vivo; vein blood from workers exposed to styrene in two factories. The data showed that there was a good linear dose-response relationship between reacting dose of styrene oxide or styrene and amount of protein-styrene oxide adducts in both in vitro and in vivo experiments. For human samples, a close-response relationship between protein adducts and styrene exposure can be found in glass fiber factory, but not in piano manufacture plant. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Environmental Sciences (IOS Press) is the property of IOS Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 391 Subjects: – SubjectFull: Styrene oxide Type: general – SubjectFull: Styrene Type: general Titles: – TitleFull: Investigation of protein-styrene oxide adducts as a molecular biomarker of human exposed to styrene. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Liu, Shu-fen – PersonEntity: Name: NameFull: Fang, Qing-ming – PersonEntity: Name: NameFull: Jin, Zu-liang – PersonEntity: Name: NameFull: Rappaport, M. S. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2001 Type: published Y: 2001 Identifiers: – Type: issn-print Value: 10010742 Numbering: – Type: volume Value: 13 – Type: issue Value: 4 Titles: – TitleFull: Journal of Environmental Sciences (IOS Press) Type: main |
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