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Bioinspired oxidized mRNA lipid nanoparticles for ex vivo engineering of chimeric antigen receptor macrophages targeting solid tumors.

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Title: Bioinspired oxidized mRNA lipid nanoparticles for ex vivo engineering of chimeric antigen receptor macrophages targeting solid tumors.
Authors: Mukalel, Alvin J.1, Tylek, Tina2, Geisler, Hannah C.1, O'Brien, Erin2, Frazee, Caitlin1, Li, Jacqueline1, Thatte, Ajay S.1, Safford, Hannah C.1, Figueroa‐Espada, Christian G.1, Alameh, Mohamad‐Gabriel3, Hamilton, Alex G.1, Mai, David1,4,5, Sheppard, Neil C.4,5,6, June, Carl H.4,5,6, Weissman, Drew3,4, Spiller, Kara L.2, Mitchell, Michael J.1,4,7,8,9,10,11, mjmitch@seas.upenn.edu
Source: Bioengineering & Translational Medicine; May2026, Vol. 11 Issue 3, p1-22, 22p
Database: Applied Science & Technology Source
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ISSN:23806761
DOI:10.1002/btm2.70138