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Structure-optimization and structure-activity relationship of diphenylpyrazinyl aminoalkoxyacetic acid derivatives: piperidine substitution and hydrophobic modification as key strategies for IP receptor agonists.

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Title: Structure-optimization and structure-activity relationship of diphenylpyrazinyl aminoalkoxyacetic acid derivatives: piperidine substitution and hydrophobic modification as key strategies for IP receptor agonists.
Authors: Cai, Xianrong1, Gao, Liyan1, Cheng, Juping1, Wang, Yuhe1, Liu, Guiying1, Ma, Xiaoyan1, Fu, Qingquan1, Lu, Jingguang1, An, Xiaoli1, Anxl23@suse.edu.cn, Mu, Zhenqiang2, 10976@cqmpc.edu.cn
Source: Journal of Computer-Aided Molecular Design; 7/23/2026, Vol. 40 Issue 1, p1-12, 12p
Database: Applied Science & Technology Source
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Header DbId: aci
DbLabel: Applied Science & Technology Source
An: 195542970
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Structure-optimization and structure-activity relationship of diphenylpyrazinyl aminoalkoxyacetic acid derivatives: piperidine substitution and hydrophobic modification as key strategies for IP receptor agonists.
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  Data: <searchLink fieldCode="AU" term="%22Cai%2C+Xianrong%22">Cai, Xianrong</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AU" term="%22Gao%2C+Liyan%22">Gao, Liyan</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AU" term="%22Cheng%2C+Juping%22">Cheng, Juping</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AU" term="%22Wang%2C+Yuhe%22">Wang, Yuhe</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AU" term="%22Liu%2C+Guiying%22">Liu, Guiying</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AU" term="%22Ma%2C+Xiaoyan%22">Ma, Xiaoyan</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AU" term="%22Fu%2C+Qingquan%22">Fu, Qingquan</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AU" term="%22Lu%2C+Jingguang%22">Lu, Jingguang</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AU" term="%22An%2C+Xiaoli%22">An, Xiaoli</searchLink><relatesTo>1</relatesTo>, <i>Anxl23@suse.edu.cn</i><br /><searchLink fieldCode="AU" term="%22Mu%2C+Zhenqiang%22">Mu, Zhenqiang</searchLink><relatesTo>2</relatesTo>, <i>10976@cqmpc.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Computer-Aided+Molecular+Design%22">Journal of Computer-Aided Molecular Design</searchLink>; 7/23/2026, Vol. 40 Issue 1, p1-12, 12p
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=aci&AN=195542970
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      – Type: doi
        Value: 10.1007/s10822-026-00886-3
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      – Code: eng
        Text: English
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        PageCount: 12
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      – TitleFull: Structure-optimization and structure-activity relationship of diphenylpyrazinyl aminoalkoxyacetic acid derivatives: piperidine substitution and hydrophobic modification as key strategies for IP receptor agonists.
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            – D: 23
              M: 07
              Text: 7/23/2026
              Type: published
              Y: 2026
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              Value: 40
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