Synergistic targeted inhibition of MEK and dual PI3K/ mTOR diminishes viability and inhibits tumor growth of canine melanoma underscoring its utility as a preclinical model for human mucosal melanoma.

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Title: Synergistic targeted inhibition of MEK and dual PI3K/ mTOR diminishes viability and inhibits tumor growth of canine melanoma underscoring its utility as a preclinical model for human mucosal melanoma.
Authors: Wei, Bih‐Rong1,2, Michael, Helen T.1, Halsey, Charles H.C.1, Peer, Cody J.3, Adhikari, Amit2,4, Dwyer, Jennifer E.1, Hoover, Shelley B.1, El Meskini, Rajaa2,4, Kozlov, Serguei2,4, Weaver Ohler, Zoe2,4, Figg, William. D.3, Merlino, Glenn1, Simpson, R. Mark1 ms43b@nih.gov
Source: Pigment Cell & Melanoma Research. Nov2016, Vol. 29 Issue 6, p643-655. 14p.
Database: Academic Search Ultimate
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ISSN:17551471
DOI:10.1111/pcmr.12512