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Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA).

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Title: Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA).
Authors: Gopalsamy, Ariamala1 ariamala.gopalsamy@pfizer.com, Narayanan, Arjun1, Shenping Liu2, Parikh, Mihir D.2, Kyne Jr., Robert E.2, Fadeyi, Olugbeminiyi2, Tones, Michael A.3, Cherry, Jonathan J.3, Nabhan, Joseph F.3, LaRosa, Gregory3, Petersen, Donna N.4, Menard, Carol4, Foley, Timothy L.4, Noell, Stephen4, Ren, Yong4, Loria, Paula M.4, Maglich-Goodwin, Jodi1, Haojing Rong5, Jones, Lyn H.1
Source: Journal of Medicinal Chemistry. 4/13/2017, Vol. 60 Issue 7, p3094-3108. 15p.
Database: Academic Search Ultimate
Description
ISSN:00222623
DOI:10.1021/acs.jmedchem.7b00124