Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA).

Saved in:
Bibliographic Details
Title: Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA).
Authors: Gopalsamy, Ariamala1 ariamala.gopalsamy@pfizer.com, Narayanan, Arjun1, Shenping Liu2, Parikh, Mihir D.2, Kyne Jr., Robert E.2, Fadeyi, Olugbeminiyi2, Tones, Michael A.3, Cherry, Jonathan J.3, Nabhan, Joseph F.3, LaRosa, Gregory3, Petersen, Donna N.4, Menard, Carol4, Foley, Timothy L.4, Noell, Stephen4, Ren, Yong4, Loria, Paula M.4, Maglich-Goodwin, Jodi1, Haojing Rong5, Jones, Lyn H.1
Source: Journal of Medicinal Chemistry. 4/13/2017, Vol. 60 Issue 7, p3094-3108. 15p.
Database: Academic Search Ultimate
FullText Text:
  Availability: 0
Header DbId: asn
DbLabel: Academic Search Ultimate
An: 122530063
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA).
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Gopalsamy%2C+Ariamala%22">Gopalsamy, Ariamala</searchLink><relatesTo>1</relatesTo><i> ariamala.gopalsamy@pfizer.com</i><br /><searchLink fieldCode="AR" term="%22Narayanan%2C+Arjun%22">Narayanan, Arjun</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Shenping+Liu%22">Shenping Liu</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Parikh%2C+Mihir+D%2E%22">Parikh, Mihir D.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Kyne+Jr%2E%2C+Robert+E%2E%22">Kyne Jr., Robert E.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Fadeyi%2C+Olugbeminiyi%22">Fadeyi, Olugbeminiyi</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Tones%2C+Michael+A%2E%22">Tones, Michael A.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Cherry%2C+Jonathan+J%2E%22">Cherry, Jonathan J.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Nabhan%2C+Joseph+F%2E%22">Nabhan, Joseph F.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22LaRosa%2C+Gregory%22">LaRosa, Gregory</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Petersen%2C+Donna+N%2E%22">Petersen, Donna N.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Menard%2C+Carol%22">Menard, Carol</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Foley%2C+Timothy+L%2E%22">Foley, Timothy L.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Noell%2C+Stephen%22">Noell, Stephen</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Ren%2C+Yong%22">Ren, Yong</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Loria%2C+Paula+M%2E%22">Loria, Paula M.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Maglich-Goodwin%2C+Jodi%22">Maglich-Goodwin, Jodi</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Haojing+Rong%22">Haojing Rong</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Jones%2C+Lyn+H%2E%22">Jones, Lyn H.</searchLink><relatesTo>1</relatesTo>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Journal+of+Medicinal+Chemistry%22">Journal of Medicinal Chemistry</searchLink>. 4/13/2017, Vol. 60 Issue 7, p3094-3108. 15p.
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=122530063
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1021/acs.jmedchem.7b00124
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 15
        StartPage: 3094
    Titles:
      – TitleFull: Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA).
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Gopalsamy, Ariamala
      – PersonEntity:
          Name:
            NameFull: Narayanan, Arjun
      – PersonEntity:
          Name:
            NameFull: Shenping Liu
      – PersonEntity:
          Name:
            NameFull: Parikh, Mihir D.
      – PersonEntity:
          Name:
            NameFull: Kyne Jr., Robert E.
      – PersonEntity:
          Name:
            NameFull: Fadeyi, Olugbeminiyi
      – PersonEntity:
          Name:
            NameFull: Tones, Michael A.
      – PersonEntity:
          Name:
            NameFull: Cherry, Jonathan J.
      – PersonEntity:
          Name:
            NameFull: Nabhan, Joseph F.
      – PersonEntity:
          Name:
            NameFull: LaRosa, Gregory
      – PersonEntity:
          Name:
            NameFull: Petersen, Donna N.
      – PersonEntity:
          Name:
            NameFull: Menard, Carol
      – PersonEntity:
          Name:
            NameFull: Foley, Timothy L.
      – PersonEntity:
          Name:
            NameFull: Noell, Stephen
      – PersonEntity:
          Name:
            NameFull: Ren, Yong
      – PersonEntity:
          Name:
            NameFull: Loria, Paula M.
      – PersonEntity:
          Name:
            NameFull: Maglich-Goodwin, Jodi
      – PersonEntity:
          Name:
            NameFull: Haojing Rong
      – PersonEntity:
          Name:
            NameFull: Jones, Lyn H.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 13
              M: 04
              Text: 4/13/2017
              Type: published
              Y: 2017
          Identifiers:
            – Type: issn-print
              Value: 00222623
          Numbering:
            – Type: volume
              Value: 60
            – Type: issue
              Value: 7
          Titles:
            – TitleFull: Journal of Medicinal Chemistry
              Type: main
ResultId 1