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Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation.

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Bibliographic Details
Title: Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation.
Authors: McAllister, Laura A.1 laura.mcallister@pfizer.com, Butler, Christopher R.1, Mente, Scot1, O'Neil, Steven V.2, Fonseca, Kari R.1, Piro, Justin R.1, Cianfrogna, Julie A.2, Foley, Timothy L.2, Gilbert, Adam M.2, Harris, Anthony R.2, Helal, Christopher J.2, Johnson, Douglas S.1, Montgomery, Justin I.2, Nason, Deane M.2, Noell, Stephen2, Pandit, Jayvardhan2, Rogers, Bruce N.1, Samad, Tarek A.1, Shaffer, Christopher L.1, Silva, Rafael G. da2
Source: Journal of Medicinal Chemistry. 4/12/2018, Vol. 61 Issue 7, p3008-3026. 19p.
Database: Academic Search Ultimate
Description
ISSN:00222623
DOI:10.1021/acs.jmedchem.8b00070