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Development of potent dual PDK1/AurA kinase inhibitors for cancer therapy: Lead-optimization, structural insights, and ADME-Tox profile.

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Title: Development of potent dual PDK1/AurA kinase inhibitors for cancer therapy: Lead-optimization, structural insights, and ADME-Tox profile.
Authors: Sestito, Simona1 (AUTHOR), Bacci, Andrea1 (AUTHOR), Chiarugi, Sara2,3 (AUTHOR), Runfola, Massimiliano1 (AUTHOR), Gado, Francesca1 (AUTHOR), Margheritis, Eleonora2 (AUTHOR), Gul, Sheraz4,5 (AUTHOR), Riveiro, Maria E.1,6 (AUTHOR) eugenia.riveiro@e2dg.com, Vazquez, Ramiro6 (AUTHOR), Huguet, Samuel7 (AUTHOR), Manera, Clementina1 (AUTHOR), Rezai, Keyvan7 (AUTHOR), Garau, Gianpiero1,2 (AUTHOR) gianpiero.garau@iit.it, Rapposelli, Simona1,8 (AUTHOR) simona.rapposelli@unipi.it
Source: European Journal of Medicinal Chemistry. Dec2021, Vol. 226, pN.PAG-N.PAG. 1p.
Database: Academic Search Ultimate
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DbLabel: Academic Search Ultimate
An: 153623077
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Development of potent dual PDK1/AurA kinase inhibitors for cancer therapy: Lead-optimization, structural insights, and ADME-Tox profile.
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Medicinal+Chemistry%22">European Journal of Medicinal Chemistry</searchLink>. Dec2021, Vol. 226, pN.PAG-N.PAG. 1p.
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=153623077
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      – Type: doi
        Value: 10.1016/j.ejmech.2021.113895
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      – Code: eng
        Text: English
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      – TitleFull: Development of potent dual PDK1/AurA kinase inhibitors for cancer therapy: Lead-optimization, structural insights, and ADME-Tox profile.
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              Text: Dec2021
              Type: published
              Y: 2021
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              Value: 226
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