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A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models.

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Title: A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models.
Authors: Singh, Dharaminder1 (AUTHOR) Dharaminder.Singh@CN-Bio.com, Deosarkar, Sudhir P.2 (AUTHOR), Cadogan, Elaine3 (AUTHOR), Flemington, Vikki3 (AUTHOR), Bray, Alysha1 (AUTHOR), Zhang, Jingwen4 (AUTHOR), Reiserer, Ronald S.5 (AUTHOR), Schaffer, David K.5 (AUTHOR), Gerken, Gregory B.5 (AUTHOR), Britt, Clayton M.5 (AUTHOR), Werner, Erik M.5 (AUTHOR), Gibbons, Francis D.6 (AUTHOR), Kostrzewski, Tomasz1 (AUTHOR), Chambers, Christopher E.3 (AUTHOR), Davies, Emma J.3 (AUTHOR), Montoya, Antonio Ramos3 (AUTHOR), Fok, Jacqueline H. L.3 (AUTHOR), Hughes, David1 (AUTHOR), Fabre, Kristin7 (AUTHOR), Wagoner, Matthew P.2 (AUTHOR)
Source: PLoS Biology. 5/26/2022, Vol. 20 Issue 5, p1-17. 17p. 1 Diagram, 4 Graphs.
Database: Academic Search Ultimate
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ISSN:15449173
DOI:10.1371/journal.pbio.3001624