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Dose-dependent reduction of somatic expansions but not Htt aggregates by di-valent siRNA-mediated silencing of MSH3 in HdhQ111 mice.

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Title: Dose-dependent reduction of somatic expansions but not Htt aggregates by di-valent siRNA-mediated silencing of MSH3 in HdhQ111 mice.
Authors: Driscoll, Rachelle1 (AUTHOR), Hampton, Lucas2 (AUTHOR), Abraham, Neeta A.2 (AUTHOR), Larigan, J. Douglas3 (AUTHOR), Joseph, Nadine F.2 (AUTHOR), Hernandez-Vega, Juan C.2 (AUTHOR), Geisler, Sarah1 (AUTHOR), Yang, Fu-Chia1 (AUTHOR), Deninger, Matthew4 (AUTHOR), Tran, David T.4 (AUTHOR), Khatri, Natasha4 (AUTHOR), Godinho, Bruno M. D. C.4 (AUTHOR), Kinberger, Garth A.4 (AUTHOR), Montagna, Daniel R.2 (AUTHOR), Hirst, Warren D.2 (AUTHOR), Guardado, Catherine L.2 (AUTHOR), Glajch, Kelly E.2 (AUTHOR), Arnold, H. Moore1 (AUTHOR), Gallant-Behm, Corrie L.4 (AUTHOR), Weihofen, Andreas2 (AUTHOR) andreas.weihofen@biogen.com
Source: Scientific Reports. 1/24/2024, Vol. 14 Issue 1, p1-11. 11p.
Database: Academic Search Ultimate
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ISSN:20452322
DOI:10.1038/s41598-024-52667-3