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A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants.

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Title: A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants.
Authors: Ferreira, Letícia Tiburcio1,2,3 (AUTHOR), Cassiano, Gustavo Capatti4 (AUTHOR), Alvarez, Luis Carlos Salazar1 (AUTHOR), Okombo, John2,3 (AUTHOR), Calit, Juliana5 (AUTHOR), Fontinha, Diana6 (AUTHOR), Gil-Iturbe, Eva7 (AUTHOR), Coyle, Rachael8,9 (AUTHOR), Andrade, Carolina Horta10,11,12 (AUTHOR), Sunnerhagen, Per13 (AUTHOR), Bargieri, Daniel Youssef5 (AUTHOR), Prudêncio, Miguel6 (AUTHOR), Quick, Matthias7,14,15 (AUTHOR), Cravo, Pedro V.4 (AUTHOR), Lee, Marcus C. S.8,9 (AUTHOR), Fidock, David A.2,3,16 (AUTHOR) df2260@cumc.columbia.edu, Costa, Fabio Trindade Maranhão1,4 (AUTHOR) fabiotmc72@gmail.com
Source: PLoS Pathogens. 10/29/2024, Vol. 20 Issue 10, p1-25. 25p.
Database: Academic Search Ultimate
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ISSN:15537366
DOI:10.1371/journal.ppat.1012627