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Stochastic demethylation and redundant epigenetic suppressive mechanisms generate highly heterogeneous responses to pharmacological DNA methyltransferase inhibition.

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Title: Stochastic demethylation and redundant epigenetic suppressive mechanisms generate highly heterogeneous responses to pharmacological DNA methyltransferase inhibition.
Authors: Jakobsen, Mie K.1 (AUTHOR), Traynor, Sofie1 (AUTHOR), Nielsen, Aaraby Y.1 (AUTHOR), Dahl, Christina2 (AUTHOR), Staehr, Mette1 (AUTHOR), Jakobsen, Simon T.3 (AUTHOR), Madsen, Maria S.3 (AUTHOR), Siersbaek, Rasmus3 (AUTHOR), Terp, Mikkel G.1 (AUTHOR), Jensen, Josefine B.1 (AUTHOR), Pedersen, Christina B.1 (AUTHOR), Shrestha, Anup3 (AUTHOR), Brewer, Jonathan R.3 (AUTHOR), Duijf, Pascal H. G.4,5,6 (AUTHOR), Gammelgaard, Odd L.1 (AUTHOR), Ditzel, Henrik J.1,7,8 (AUTHOR), Kirkin, Alexei F.9 (AUTHOR), Guldberg, Per1,2 (AUTHOR), Gjerstorff, Morten F.1,7,8 (AUTHOR) mgjerstorff@health.sdu.dk
Source: Journal of Experimental & Clinical Cancer Research (17569966). 1/23/2025, Vol. 44 Issue 1, p1-15. 15p.
Database: Academic Search Ultimate
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ISSN:17569966
DOI:10.1186/s13046-025-03294-x