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γ-Secretase modulator resistance of an aggressive Alzheimer-causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compounds.

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Title: γ-Secretase modulator resistance of an aggressive Alzheimer-causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compounds.
Authors: Trambauer, Johannes1,2 (AUTHOR), Sarmiento, Rosa Maria Rodriguez3 (AUTHOR), Garringer, Holly J.4 (AUTHOR), Salbaum, Katja5 (AUTHOR), Pedro, Liliana D.2,5 (AUTHOR), Crusius, Dennis5 (AUTHOR), Vidal, Ruben4 (AUTHOR), Ghetti, Bernardino4 (AUTHOR), Paquet, Dominik5,6 (AUTHOR), Baumann, Karlheinz7 (AUTHOR), Lindemann, Lothar7 (AUTHOR), Steiner, Harald1,2 (AUTHOR) harald.steiner@med.uni-muenchen.de
Source: Alzheimer's Research & Therapy. 2/19/2025, Vol. 17 Issue 1, p1-19. 19p.
Database: Academic Search Ultimate
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ISSN:17589193
DOI:10.1186/s13195-025-01680-3