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The protective PLCγ2-P522R variant mitigates Alzheimer's disease-associated pathologies by enhancing beneficial microglial functions.

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Title: The protective PLCγ2-P522R variant mitigates Alzheimer's disease-associated pathologies by enhancing beneficial microglial functions.
Authors: Takalo, Mari1 (AUTHOR) mari.takalo@uef.fi, Jeskanen, Heli1 (AUTHOR), Rolova, Taisia2 (AUTHOR), Kervinen, Inka1 (AUTHOR), Hellén, Marianna2 (AUTHOR), Heikkinen, Sami1 (AUTHOR), Koivisto, Hennariikka3 (AUTHOR), Jokivarsi, Kimmo3 (AUTHOR), Müller, Stephan A.4,5 (AUTHOR), Koivumäki, Esa-Mikko6,7 (AUTHOR), Mäkinen, Petra1 (AUTHOR), Juopperi, Sini-Pauliina1 (AUTHOR), Willman, Roosa-Maria1 (AUTHOR), Sinisalo, Rosa1 (AUTHOR), Hoffmann, Dorit3 (AUTHOR), Jäntti, Henna3 (AUTHOR), Peitz, Michael8,9 (AUTHOR), Fließbach, Klaus10,11 (AUTHOR), Kuulasmaa, Teemu1 (AUTHOR), Natunen, Teemu1 (AUTHOR)
Source: Journal of Neuroinflammation. 3/5/2025, Vol. 22 Issue 1, p1-30. 30p.
Database: Academic Search Ultimate
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Description
ISSN:17422094
DOI:10.1186/s12974-025-03387-6