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Tetrahydrobenzimidazole TMQ0153 targets OPA1 and restores drug sensitivity in AML via ROS-induced mitochondrial metabolic reprogramming.

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Title: Tetrahydrobenzimidazole TMQ0153 targets OPA1 and restores drug sensitivity in AML via ROS-induced mitochondrial metabolic reprogramming.
Authors: Park, Su Jung1 (AUTHOR), Cerella, Claudia2,3 (AUTHOR), Kang, Jin Mo1 (AUTHOR), Byun, Jinyoung4 (AUTHOR), Kum, David1 (AUTHOR), Orlikova-Boyer, Barbora2,3 (AUTHOR), Lorant, Anne2,5 (AUTHOR), Schnekenburger, Michael2,3 (AUTHOR), Al-Mourabit, Ali6 (AUTHOR), Christov, Christo7 (AUTHOR), Lee, Juyong4,8 (AUTHOR), Han, Byung Woo1 (AUTHOR), Diederich, Marc1 (AUTHOR) marcdiederich@snu.ac.kr
Source: Journal of Experimental & Clinical Cancer Research (17569966). 4/7/2025, Vol. 44 Issue 1, p1-28. 28p.
Database: Academic Search Ultimate
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ISSN:17569966
DOI:10.1186/s13046-025-03372-0