Modulation of senescent Lepr+ skeletal stem cells via suppression of leptin-induced STAT3‒FGF7 axis activation alleviates abnormal subchondral bone remodeling and osteoarthritis progression.

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Title: Modulation of senescent Lepr+ skeletal stem cells via suppression of leptin-induced STAT3‒FGF7 axis activation alleviates abnormal subchondral bone remodeling and osteoarthritis progression.
Authors: Yu, Fu-Hao1,2,3,4 (AUTHOR), Yin, Bo-Feng1,2 (AUTHOR), Liu, Ming-Yu1,2,3,4 (AUTHOR), Zhang, Wen-Jing1,2 (AUTHOR), Zhao, Zhi-Dong5 (AUTHOR), Wang, Lei5 (AUTHOR), Li, Xiao-Tong1,2 (AUTHOR), Li, Pei-Lin1,2 (AUTHOR), Li, Zhi-Ling1,2 (AUTHOR), Xu, Run-Xiang1,2,3,4 (AUTHOR), Ding, Li3,4,6 (AUTHOR) dingli7578@163.com, Zhu, Heng1,2,6,7 (AUTHOR) zhudingdingabc@163.com
Source: Stem Cell Research & Therapy. 5/5/2025, Vol. 16 Issue 1, p1-20. 20p.
Database: Academic Search Ultimate
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ISSN:17576512
DOI:10.1186/s13287-025-04342-1