Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma.

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Title: Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma.
Authors: Lin, Benjamin1,2 (AUTHOR), Shelton, Abigail K.2 (AUTHOR), Smithberger, Erin2 (AUTHOR), Ziebro, Julia2 (AUTHOR), Skinner, Kasey R.2 (AUTHOR), Bash, Ryan E.2 (AUTHOR), Kirkman, Richard2 (AUTHOR), Stamper, Allie2 (AUTHOR), Butler, Madison3 (AUTHOR), Flores, Alex4 (AUTHOR), Angus, Steven P.5 (AUTHOR), East, Michael P.6 (AUTHOR), Cloughesy, Timothy F.7 (AUTHOR), Nathanson, David A.8 (AUTHOR), Berens, Michael E.9 (AUTHOR), Sarkaria, Jann N.10 (AUTHOR), Binder, Zev A.11 (AUTHOR), O'Rourke, Donald M.11 (AUTHOR), Howton, Timothy C.12 (AUTHOR), Lasseigne, Brittany N.12,13,14 (AUTHOR)
Source: Acta Neuropathologica Communications. 6/28/2025, Vol. 13 Issue 1, p1-17. 17p.
Database: Academic Search Ultimate
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ISSN:20515960
DOI:10.1186/s40478-025-02068-y