Safety, tolerability, pharmacokinetic and pharmacodynamic effects of the muscarinic M1 positive allosteric modulator VU0467319 for Alzheimer's disease: a single ascending-dose study in healthy participants.

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Title: Safety, tolerability, pharmacokinetic and pharmacodynamic effects of the muscarinic M1 positive allosteric modulator VU0467319 for Alzheimer's disease: a single ascending-dose study in healthy participants.
Authors: Conley, Alexander C.1 (AUTHOR), Key, Alexandra P.1,2 (AUTHOR), Blackford, Jennifer U.1,3 (AUTHOR), Russell, Jason K.1,4 (AUTHOR), Albert, Kimberly M.1 (AUTHOR), Gong, Xuewen1 (AUTHOR), Bubser, Michael5,6 (AUTHOR), Rook, Jerri M.5,6 (AUTHOR), Conn, P. Jeffrey5,6 (AUTHOR), Lindsley, Craig W.5,6 (AUTHOR), Jones, Carrie K.5,6 (AUTHOR), Newhouse, Paul A.1 (AUTHOR) paul.newhouse@vanderbilt.edu
Source: Alzheimer's Research & Therapy. 7/1/2025, Vol. 17 Issue 1, p1-18. 18p.
Database: Academic Search Ultimate
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ISSN:17589193
DOI:10.1186/s13195-025-01798-4