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Is noxious stimulus-evoked electroencephalography response a reliable, valid, and interpretable outcome measure to assess analgesic efficacy in neonates? A systematic review and individual participant data (IPD) meta-analysis protocol.

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Title: Is noxious stimulus-evoked electroencephalography response a reliable, valid, and interpretable outcome measure to assess analgesic efficacy in neonates? A systematic review and individual participant data (IPD) meta-analysis protocol.
Authors: Baxter, Luke1,2 (AUTHOR) luke.baxter@paediatrics.ox.ac.uk, van der Vaart, Marianne1 (AUTHOR), Cobo, Maria M.1,3 (AUTHOR), Gunawan, Patricia Y.1,4 (AUTHOR), Allegaert, Karel5,6,7 (AUTHOR), Davis, Jonathan M.8 (AUTHOR), Turner, Mark9 (AUTHOR), Ward, Robert M.10 (AUTHOR), Darsey, Edress11 (AUTHOR), Sheppard, James P.12 (AUTHOR), Bhatt, Aomesh1 (AUTHOR), van den Anker, John1,13 (AUTHOR), Massaro, An N.14 (AUTHOR), Walls, Ramona L.15 (AUTHOR), Song, Laura S.15 (AUTHOR), Singh, Kanwaljit16 (AUTHOR), Apele-Freimane, Dina (AUTHOR), Arimistu, Takeshi (AUTHOR), Barry, Christine (AUTHOR), Discenza, Deb (AUTHOR)
Source: Systematic Reviews. 7/30/2025, Vol. 14 Issue 1, p1-9. 9p.
Database: Academic Search Ultimate
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ISSN:20464053
DOI:10.1186/s13643-025-02890-4