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Casdatifan (AB521) is a novel and potent allosteric small molecule inhibitor of protumourigenic HIF‐2α dependent transcription.

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Title: Casdatifan (AB521) is a novel and potent allosteric small molecule inhibitor of protumourigenic HIF‐2α dependent transcription.
Authors: Schweickert, Patrick G.1 (AUTHOR), Piovesan, Dana1 (AUTHOR), Mitchell, Casey G.1 (AUTHOR), Zepeda‐Carranza, Bryan1 (AUTHOR), Zhu, Wandi S.1 (AUTHOR), Lopez Espinoza, Alejandra Y.1 (AUTHOR), Rocha, Lauren1 (AUTHOR), Singh, Jaskirat1 (AUTHOR), Malgapo, Martin Ian P.1 (AUTHOR), Meleza, Cesar1 (AUTHOR), Northington, Kyle R.1 (AUTHOR), Ray, Rebecca D.1 (AUTHOR), Zhao, Xiaoning1 (AUTHOR), Lawson, Kenneth V.1 (AUTHOR), Walters, Matthew J.1 (AUTHOR), Sivick, Kelsey E.1 (AUTHOR) ksivick@arcusbio.com
Source: British Journal of Pharmacology. Sep2025, Vol. 182 Issue 17, p4147-4167. 21p.
Database: Academic Search Ultimate
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ISSN:00071188
DOI:10.1111/bph.70075