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Casdatifan (AB521) is a novel and potent allosteric small molecule inhibitor of protumourigenic HIF‐2α dependent transcription.

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Title: Casdatifan (AB521) is a novel and potent allosteric small molecule inhibitor of protumourigenic HIF‐2α dependent transcription.
Authors: Schweickert, Patrick G.1 (AUTHOR), Piovesan, Dana1 (AUTHOR), Mitchell, Casey G.1 (AUTHOR), Zepeda‐Carranza, Bryan1 (AUTHOR), Zhu, Wandi S.1 (AUTHOR), Lopez Espinoza, Alejandra Y.1 (AUTHOR), Rocha, Lauren1 (AUTHOR), Singh, Jaskirat1 (AUTHOR), Malgapo, Martin Ian P.1 (AUTHOR), Meleza, Cesar1 (AUTHOR), Northington, Kyle R.1 (AUTHOR), Ray, Rebecca D.1 (AUTHOR), Zhao, Xiaoning1 (AUTHOR), Lawson, Kenneth V.1 (AUTHOR), Walters, Matthew J.1 (AUTHOR), Sivick, Kelsey E.1 (AUTHOR) ksivick@arcusbio.com
Source: British Journal of Pharmacology. Sep2025, Vol. 182 Issue 17, p4147-4167. 21p.
Database: Academic Search Ultimate
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  Data: Casdatifan (AB521) is a novel and potent allosteric small molecule inhibitor of protumourigenic HIF‐2α dependent transcription.
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  Data: <searchLink fieldCode="JN" term="%22British+Journal+of+Pharmacology%22">British Journal of Pharmacology</searchLink>. Sep2025, Vol. 182 Issue 17, p4147-4167. 21p.
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=187112852
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              Text: Sep2025
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