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Combinatorial DNMTs and EZH2 inhibition reprograms the H3K27me3 and DNAme-mediated onco-epigenome to suppress multiple myeloma proliferation.

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Title: Combinatorial DNMTs and EZH2 inhibition reprograms the H3K27me3 and DNAme-mediated onco-epigenome to suppress multiple myeloma proliferation.
Authors: Atienza Párraga, Alba1 (AUTHOR), Nylund, Patrick1 (AUTHOR), Diamanti, Klev1,2 (AUTHOR), Garrido-Zabala, Berta1 (AUTHOR), Tziola, Stefania Iliana1 (AUTHOR), Vasquez, Louella3 (AUTHOR), Pyl, Paul Theodor3 (AUTHOR), Raykova, Doroteya4 (AUTHOR), Skaftason, Aron1 (AUTHOR), Ma, Anqi5 (AUTHOR), Jin, Jian5 (AUTHOR), Martín-Subero, José Ignacio6,7 (AUTHOR), Öberg, Fredrik1,8 (AUTHOR), De Bruyne, Elke9 (AUTHOR), Komorowski, Jan2,10,11,12 (AUTHOR), Jernberg Wiklund, Helena1 (AUTHOR) helena.jernberg_wiklund@igp.uu.se, Kalushkova, Antonia1 (AUTHOR) antonia.kalushkova@igp.uu.se
Source: Scientific Reports. 8/27/2025, Vol. 15 Issue 1, p1-18. 18p.
Database: Academic Search Ultimate
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ISSN:20452322
DOI:10.1038/s41598-025-17093-z