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Recombinant cathepsins B and L promote α-synuclein clearance and restore lysosomal function in human and murine models with α-synuclein pathology.

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Title: Recombinant cathepsins B and L promote α-synuclein clearance and restore lysosomal function in human and murine models with α-synuclein pathology.
Authors: Balta, Denise1 (AUTHOR), Varghese, Anish1 (AUTHOR), Prieto Huarcaya, Susy1 (AUTHOR), Di Spiezio, Alessandro2 (AUTHOR), Marques, André R. A.3 (AUTHOR), Akdaş, Enes Yağız4 (AUTHOR), Tabakacilar, Doğa5 (AUTHOR), Drobny, Alice1 (AUTHOR), Werner, Christian6 (AUTHOR), Xiang, Wei1 (AUTHOR), Mächtel, Rebecca1 (AUTHOR), Dobert, Jan Philipp1 (AUTHOR), Fejtova, Anna4 (AUTHOR), Richter, Franziska7 (AUTHOR), Küspert, Melanie5 (AUTHOR), Arnold, Philipp8 (AUTHOR), Saftig, Paul9 (AUTHOR), Zunke, Friederike1 (AUTHOR) friederike.zunke@fau.de
Source: Molecular Neurodegeneration. 8/29/2025, Vol. 20 Issue 1, p1-27. 27p.
Database: Academic Search Ultimate
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ISSN:17501326
DOI:10.1186/s13024-025-00886-1