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Pharmacological inhibition of SPAK-NKCC1 complex attenuates astrogliosis and restores cerebral blood flow in a mouse model of VCID.

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Title: Pharmacological inhibition of SPAK-NKCC1 complex attenuates astrogliosis and restores cerebral blood flow in a mouse model of VCID.
Authors: Habib, Khadija1,2 (AUTHOR) khhabib.31@gmail.com, Sultan, Md. Tipu1,2 (AUTHOR) tipubge@yahoo.com, Jahan, Israt1,2 (AUTHOR) ijaimy@gmail.com, Rahman, Md. Shamim1,3 (AUTHOR) shamim.bge.ku12@gmail.com, Kundu, Sujan Kumar1,3 (AUTHOR) sujanku13@gmail.com, Sarker, Barnali1,3 (AUTHOR) barnalisarker16@gmail.com, Islam, Rabia4 (AUTHOR) sharmeenmn@gmail.com, Ahmed, Tanvir1 (AUTHOR) tanvir203ahmed@gmail.com, Mendez, Ian A.2 (AUTHOR) iamendez2@utep.edu, Cao, Guodong5,6 (AUTHOR) caoxgx@upmc.edu, Sun, Dandan5,6 (AUTHOR) sund@upmc.edu, Tesic, Vesna1,7 (AUTHOR) vesna.tesic@lsuhs.edu, Bhuiyan, Mohammad Iqbal H.1,2,3,7 (AUTHOR) mohammad.iqbal@lsuhs.edu
Source: Acta Neuropathologica Communications. 10/24/2025, Vol. 13 Issue 1, p1-21. 21p.
Database: Academic Search Ultimate
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ISSN:20515960
DOI:10.1186/s40478-025-02137-2