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Evolutionary turnover of key amino acids explains conservation of function without conservation of sequence in transcriptional activation domains.

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Title: Evolutionary turnover of key amino acids explains conservation of function without conservation of sequence in transcriptional activation domains.
Authors: LeBlanc, Claire J.1,2 (AUTHOR), Stefani, Jordan1,2 (AUTHOR), Soriano, Melvin1,2 (AUTHOR), Lam, Angelica1,2 (AUTHOR), Zintel, Marissa A.1 (AUTHOR), Kotha, Sanjana R.1,2 (AUTHOR), Chase, Emily1,2 (AUTHOR), Pimentel-Solorio, Giovani1,2 (AUTHOR), Vunnum, Aditya1 (AUTHOR), Hu, Gean1 (AUTHOR), Flug, Katherine1 (AUTHOR), Fultineer, Aaron3 (AUTHOR), Hummel, Niklas4 (AUTHOR), Staller, Max V.1,2,5 (AUTHOR) mstaller@berkeley.edu
Source: PLoS Genetics. 3/16/2026, Vol. 22 Issue 3, p1-37. 37p.
Database: Academic Search Ultimate
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ISSN:15537390
DOI:10.1371/journal.pgen.1012069