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NRF2 activators and the inhibitor of nuclear export, selinexor, restrict coronaviruses by targeting a network involving ACE2, TMPRSS2, and XPO1 through an NRF2-independent mechanism.

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Title: NRF2 activators and the inhibitor of nuclear export, selinexor, restrict coronaviruses by targeting a network involving ACE2, TMPRSS2, and XPO1 through an NRF2-independent mechanism.
Authors: Waqas, Fakhar H.1,2 (AUTHOR), Silva da Costa, Leandro3 (AUTHOR), Zapatero-Belinchón, Francisco J.4,5 (AUTHOR), Carter-Timofte, Madalina E.3 (AUTHOR), Lasswitz, Lisa4 (AUTHOR), van der Horst, Demi3,6 (AUTHOR), Möller, Rebecca4,7 (AUTHOR), Dahlmann, Julia8,9 (AUTHOR), Olmer, Ruth8,9 (AUTHOR), Geffers, Robert10 (AUTHOR), Gerold, Gisa4,11 (AUTHOR), Olagnier, David3 (AUTHOR), Pessler, Frank1,2,12 (AUTHOR) frank.pessler@helmholtz-hzi.de
Source: Communications Biology. 2/20/2026, Vol. 9 Issue 1, p1-17. 17p.
Database: Academic Search Ultimate
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ISSN:23993642
DOI:10.1038/s42003-026-09724-6