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TH5487 specifically targets NLRP3 in FCAS patients resistant to MCC950.

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Title: TH5487 specifically targets NLRP3 in FCAS patients resistant to MCC950.
Authors: Lackner, Angela1 (AUTHOR), Picucci, Sofia I.1 (AUTHOR), Jiang, Wenjin1 (AUTHOR), Onyuru, Janset2 (AUTHOR), Campos, Melissa3 (AUTHOR), Cabral, Julia E.1 (AUTHOR), Leonidas, Lemuel1 (AUTHOR), Macapagal, Alijah1 (AUTHOR), Lee, Hannah1 (AUTHOR), Henriquez, Valerie1 (AUTHOR), Wang, Karen1 (AUTHOR), Xu, Huilin1 (AUTHOR), Qiu, Yanfei1 (AUTHOR), Albrecht, Lauren V.3,4 (AUTHOR), Hoffman, Hal M.2 (AUTHOR), McNulty, Reginald1,4 (AUTHOR) rmcnulty@uci.edu
Source: Communications Biology. 4/16/2026, Vol. 9 Issue 1, p1-17. 17p.
Database: Academic Search Ultimate
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ISSN:23993642
DOI:10.1038/s42003-026-10008-2