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Disrupting the KRAS–SOS1 protein–protein interaction: mechanistic rationale for pan-KRAS pathway suppression and combination therapy.

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Title: Disrupting the KRAS–SOS1 protein–protein interaction: mechanistic rationale for pan-KRAS pathway suppression and combination therapy.
Authors: Kamel, Emadeldin M.1 (AUTHOR) emad.abdelhameed@science.bsu.edu.eg, Khadrawy, Sally Mostafa2 (AUTHOR), Ali, Mohamed A. M.2 (AUTHOR), Abukhadra, Mostafa R.3 (AUTHOR) emad.abdelhameed@science.bsu.edu.eg, Yassin, Nour Y. S.4 (AUTHOR), Alkhedhairi, Saleh5 (AUTHOR), Aba Alkhayl, Faris F.6 (AUTHOR), Lamsabhi, Al Mokhtar7 (AUTHOR)
Source: Frontiers in Chemistry. 2026, p1-25. 25p.
Database: Academic Search Ultimate
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ISSN:22962646
DOI:10.3389/fchem.2026.1808601