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First‐In‐Human Safety, Pharmacokinetics, and Pharmacodynamics of VENT‐02 Freebase, a CNS‐Penetrant NLRP3 Inhibitor.

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Title: First‐In‐Human Safety, Pharmacokinetics, and Pharmacodynamics of VENT‐02 Freebase, a CNS‐Penetrant NLRP3 Inhibitor.
Authors: Smidt, Lisanne C. A.1,2 (AUTHOR), Moerland, Matthijs1,2 (AUTHOR), Jansen, Manon A. A.1,2 (AUTHOR), Kremer, Philip H. C.1,2 (AUTHOR), Sille, Alexandra A. J.1,2 (AUTHOR), Strugala, Pamela K.1 (AUTHOR), Klaassen, Erica S.1 (AUTHOR), Auger, Anick3 (AUTHOR), Jananji, Silvana3 (AUTHOR), Faidi, Rania3 (AUTHOR), Pike, Kelly A.3 (AUTHOR), Warner, Loraine4 (AUTHOR), Matta, Andre4 (AUTHOR), Valencia, Xavier4 (AUTHOR), Spiegelstein, Ofer4 (AUTHOR) ospiegelstein@gmail.com
Source: CTS: Clinical & Translational Science. May2026, Vol. 19 Issue 5, p1-11. 11p.
Database: Academic Search Ultimate
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ISSN:17528054
DOI:10.1111/cts.70578