A point mutation in the FAT domain constitutively increases the kinase activity of Rad3ATR and bypasses the requirement for 9-1–1 phosphorylation to activate the DNA replication checkpoint.
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| Title: | A point mutation in the FAT domain constitutively increases the kinase activity of Rad3ATR and bypasses the requirement for 9-1–1 phosphorylation to activate the DNA replication checkpoint. |
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| Authors: | Dev, Kamal1 (AUTHOR), Rider Jr., S. Dean1 (AUTHOR), Singh, Balveer1 (AUTHOR), Saini, Abhinav1 (AUTHOR), Xu, Yong-jie1 (AUTHOR) yong-jie.xu@wright.edu |
| Source: | PLoS Genetics. 6/22/2026, Vol. 22 Issue 6, p1-21. 21p. |
| Database: | Academic Search Ultimate |
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| ISSN: | 15537390 |
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| DOI: | 10.1371/journal.pgen.1012213 |