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A point mutation in the FAT domain constitutively increases the kinase activity of Rad3ATR and bypasses the requirement for 9-1–1 phosphorylation to activate the DNA replication checkpoint.

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Title: A point mutation in the FAT domain constitutively increases the kinase activity of Rad3ATR and bypasses the requirement for 9-1–1 phosphorylation to activate the DNA replication checkpoint.
Authors: Dev, Kamal1 (AUTHOR), Rider Jr., S. Dean1 (AUTHOR), Singh, Balveer1 (AUTHOR), Saini, Abhinav1 (AUTHOR), Xu, Yong-jie1 (AUTHOR) yong-jie.xu@wright.edu
Source: PLoS Genetics. 6/22/2026, Vol. 22 Issue 6, p1-21. 21p.
Database: Academic Search Ultimate
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  Data: A point mutation in the FAT domain constitutively increases the kinase activity of Rad3<superscript>ATR</superscript> and bypasses the requirement for 9-1–1 phosphorylation to activate the DNA replication checkpoint.
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  Data: <searchLink fieldCode="AR" term="%22Dev%2C+Kamal%22">Dev, Kamal</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rider+Jr%2E%2C+S%2E+Dean%22">Rider Jr., S. Dean</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Singh%2C+Balveer%22">Singh, Balveer</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Saini%2C+Abhinav%22">Saini, Abhinav</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xu%2C+Yong-jie%22">Xu, Yong-jie</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> yong-jie.xu@wright.edu</i>
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  Data: <searchLink fieldCode="JN" term="%22PLoS+Genetics%22">PLoS Genetics</searchLink>. 6/22/2026, Vol. 22 Issue 6, p1-21. 21p.
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=194756470
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        Value: 10.1371/journal.pgen.1012213
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        Text: English
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              Text: 6/22/2026
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              Y: 2026
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