Modeling, Synthesis and Biological Evaluation of Potential Retinoid X Receptor (RXR) Selective Agonists: Novel Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene).
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| Title: | Modeling, Synthesis and Biological Evaluation of Potential Retinoid X Receptor (RXR) Selective Agonists: Novel Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene). |
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| Authors: | Carl E. Wagner1, Peter W. Jurutka1, Pamela A. Marshall1, Thomas L. Groy1, Arjan van der Vaart1, Joseph W. Ziller1, Julie K. Furmick1, Mark E. Graeber1, Erik Matro1, Belinda V. Miguel1, Ivy T. Tran1, Jungeun Kwon1, Jamie N. Tedeschi1, Shahram Moosavi1, Amina Danishyar1, Joshua S. Philp1, Reina O. Khamees1, Jevon N. Jackson1, Darci K. Grupe1, Syed L. Badshah1 |
| Source: | Journal of Medicinal Chemistry. Oct2009, Vol. 52 Issue 19, p5950-5966. 17p. |
| Database: | Academic Search Ultimate |
| ISSN: | 00222623 |
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| DOI: | 10.1021/jm900496b |
