The effect of antidepressant treatment on brain-derived neurotropic factor expression in the rat hippocampus
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| Title: | The effect of antidepressant treatment on brain-derived neurotropic factor expression in the rat hippocampus |
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| Authors: | Khundakar, Ahmad Adam |
| Summary: | Enhanced BDNF expression has been implicated in the mechanisms of action of antidepressant treatment. Previous findings have shown that chronic antidepressant drug treatment produces a ’bi-phasic effect’ on total BDNF gene expression, i.e. down-regulation at 4h and up-regulation at 24h. The earlier effect is common to acute administration, while the latter is unique to chronic treatment. |
| URL: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.649953 |
| Database: | OpenDissertations |
| Abstract: | Enhanced BDNF expression has been implicated in the mechanisms of action of antidepressant treatment. Previous findings have shown that chronic antidepressant drug treatment produces a ’bi-phasic effect’ on total BDNF gene expression, i.e. down-regulation at 4h and up-regulation at 24h. The earlier effect is common to acute administration, while the latter is unique to chronic treatment. |
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