View in EDS PDF Full Text

Late enhanced computed tomography in Hypertrophic Cardiomyopathy enables accurate left-ventricular volumetry.

Saved in:
Bibliographic Details
Title: Late enhanced computed tomography in Hypertrophic Cardiomyopathy enables accurate left-ventricular volumetry.
Authors: Langer, Christoph christoph.langer@uksh.de, Both, M.1, Harders, H.2, Lutz, M., Eden, M.2, Kühl, C., Sattler, B.1, Jansen, O1, Schaefer, P.1, Frey, N.
Source: European Radiology. Feb2015, Vol. 25 Issue 2, p575-584. 10p. 3 Black and White Photographs, 2 Charts, 1 Graph.
Subjects: Computed tomography, Hypertrophy, Cardiomyopathies, Myocardial infarction, Heart diseases
Abstract: Objectives: Late enhancement (LE) multi-slice computed tomography (leMDCT) was introduced for the visualization of (intra-) myocardial fibrosis in Hypertrophic Cardiomyopathy (HCM). LE is associated with adverse cardiac events. This analysis focuses on leMDCT derived LV muscle mass (LV-MM) which may be related to LE resulting in LE proportion for potential risk stratification in HCM. Methods: N=26 HCM-patients underwent leMDCT (64-slice-CT) and cardiovascular magnetic resonance (CMR). In leMDCT iodine contrast (Iopromid, 350 mg/mL; 150mL) was injected 7 minutes before imaging. Reconstructed short cardiac axis views served for planimetry. The study group was divided into three groups of varying LV-contrast. LeMDCT was correlated with CMR. Results: The mean age was 64.2 ± 14 years. The groups of varying contrast differed in weight and body mass index ( p < 0.05). In the group with good LV-contrast assessment of LV-MM resulted in 147.4 ± 64.8 g in leMDCT vs. 147.1 ± 65.9 in CMR ( p > 0.05). In the group with sufficient contrast LV-MM appeared with 172 ± 30.8 g in leMDCT vs. 165.9 ± 37.8 in CMR ( p > 0.05). Overall intra-/inter-observer variability of semiautomatic assessment of LV-MM showed an accuracy of 0.9 ± 8.6 g and 0.8 ± 9.2 g in leMDCT. All leMDCT-measures correlated well with CMR ( r > 0.9). Conclusions: LeMDCT primarily performed for LE-visualization in HCM allows for accurate LV-volumetry including LV-MM in > 90 % of the cases. Key Points: • LeMDCT of relatively low contrast allows for LV planimetry in HCM. • The correlation of leMDCT-based LV volumetry with gold-standard CMR was excellent (r > 0.9). • LeMDCT requires approximately 2.0mL/kgBW of dye to achieve acceptable contrast. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 100372878
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Late enhanced computed tomography in Hypertrophic Cardiomyopathy enables accurate left-ventricular volumetry.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Langer%2C+Christoph%22&quot;&gt;Langer, Christoph&lt;/searchLink&gt;&lt;i&gt; christoph.langer@uksh.de&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Both%2C+M%2E%22&quot;&gt;Both, M.&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Harders%2C+H%2E%22&quot;&gt;Harders, H.&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lutz%2C+M%2E%22&quot;&gt;Lutz, M.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Eden%2C+M%2E%22&quot;&gt;Eden, M.&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22K&#252;hl%2C+C%2E%22&quot;&gt;K&#252;hl, C.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Sattler%2C+B%2E%22&quot;&gt;Sattler, B.&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Jansen%2C+O%22&quot;&gt;Jansen, O&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Schaefer%2C+P%2E%22&quot;&gt;Schaefer, P.&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Frey%2C+N%2E%22&quot;&gt;Frey, N.&lt;/searchLink&gt;
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22European+Radiology%22&quot;&gt;European Radiology&lt;/searchLink&gt;. Feb2015, Vol. 25 Issue 2, p575-584. 10p. 3 Black and White Photographs, 2 Charts, 1 Graph.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Computed+tomography%22&quot;&gt;Computed tomography&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Hypertrophy%22&quot;&gt;Hypertrophy&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cardiomyopathies%22&quot;&gt;Cardiomyopathies&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Myocardial+infarction%22&quot;&gt;Myocardial infarction&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Heart+diseases%22&quot;&gt;Heart diseases&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objectives: Late enhancement (LE) multi-slice computed tomography (leMDCT) was introduced for the visualization of (intra-) myocardial fibrosis in Hypertrophic Cardiomyopathy (HCM). LE is associated with adverse cardiac events. This analysis focuses on leMDCT derived LV muscle mass (LV-MM) which may be related to LE resulting in LE proportion for potential risk stratification in HCM. Methods: N=26 HCM-patients underwent leMDCT (64-slice-CT) and cardiovascular magnetic resonance (CMR). In leMDCT iodine contrast (Iopromid, 350 mg/mL; 150mL) was injected 7 minutes before imaging. Reconstructed short cardiac axis views served for planimetry. The study group was divided into three groups of varying LV-contrast. LeMDCT was correlated with CMR. Results: The mean age was 64.2 &#177; 14 years. The groups of varying contrast differed in weight and body mass index ( p &lt; 0.05). In the group with good LV-contrast assessment of LV-MM resulted in 147.4 &#177; 64.8 g in leMDCT vs. 147.1 &#177; 65.9 in CMR ( p &gt; 0.05). In the group with sufficient contrast LV-MM appeared with 172 &#177; 30.8 g in leMDCT vs. 165.9 &#177; 37.8 in CMR ( p &gt; 0.05). Overall intra-/inter-observer variability of semiautomatic assessment of LV-MM showed an accuracy of 0.9 &#177; 8.6 g and 0.8 &#177; 9.2 g in leMDCT. All leMDCT-measures correlated well with CMR ( r &gt; 0.9). Conclusions: LeMDCT primarily performed for LE-visualization in HCM allows for accurate LV-volumetry including LV-MM in &gt; 90 % of the cases. Key Points: • LeMDCT of relatively low contrast allows for LV planimetry in HCM. • The correlation of leMDCT-based LV volumetry with gold-standard CMR was excellent (r &gt; 0.9). • LeMDCT requires approximately 2.0mL/kgBW of dye to achieve acceptable contrast. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=100372878
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s00330-014-3434-0
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 10
        StartPage: 575
    Subjects:
      – SubjectFull: Computed tomography
        Type: general
      – SubjectFull: Hypertrophy
        Type: general
      – SubjectFull: Cardiomyopathies
        Type: general
      – SubjectFull: Myocardial infarction
        Type: general
      – SubjectFull: Heart diseases
        Type: general
    Titles:
      – TitleFull: Late enhanced computed tomography in Hypertrophic Cardiomyopathy enables accurate left-ventricular volumetry.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Langer, Christoph
      – PersonEntity:
          Name:
            NameFull: Both, M.
      – PersonEntity:
          Name:
            NameFull: Harders, H.
      – PersonEntity:
          Name:
            NameFull: Lutz, M.
      – PersonEntity:
          Name:
            NameFull: Eden, M.
      – PersonEntity:
          Name:
            NameFull: Kühl, C.
      – PersonEntity:
          Name:
            NameFull: Sattler, B.
      – PersonEntity:
          Name:
            NameFull: Jansen, O
      – PersonEntity:
          Name:
            NameFull: Schaefer, P.
      – PersonEntity:
          Name:
            NameFull: Frey, N.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 02
              Text: Feb2015
              Type: published
              Y: 2015
          Identifiers:
            – Type: issn-print
              Value: 09387994
          Numbering:
            – Type: volume
              Value: 25
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: European Radiology
              Type: main
ResultId 1