Bibliographic Details
| Title: |
Proline-Catalyzed Sequential syn-Mannich and [4 + 1]-Annulation Cascade Reactions To Form Densely Functionalized Pyrrolidines. |
| Authors: |
Aher, Ravindra D.1, Kumar, B. Senthil1, Sudalai, Arumugam1 a.sudalai@ncl.res.in |
| Source: |
Journal of Organic Chemistry. 2/6/2015, Vol. 80 Issue 3, p2024-2031. 8p. |
| Subjects: |
Annulation, Pyrrolidine derivatives, Mannich reaction, Pyrrolidine synthesis, Asymmetric synthesis |
| Abstract: |
A highly efficient one-pot [4 + 1]-annulation process for the asymmetric synthesis of densely functionalized pyrrolidine derivatives is described. The in situ generated syn-Mannich adduct obtained via proline catalysis acts as a four-atom component, and Corey's sulfur ylide or ethyl bromoacetate acts as a one-atom carbon source to construct pyrrolidine units in a highly enantio- and diastereoselective manner. [ABSTRACT FROM AUTHOR] |
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| Database: |
Engineering Source |
