Bibliographic Details
| Title: |
Cu-Catalyzed Aerobic Oxidative Cyclization of Guanidylpyridines and Derivatives. |
| Authors: |
Bartels, Björn1 bjoern.bartels@roche.com, Bolas, Conor Gordon1, Cueni, Philipp1, Fantasia, Serena2 serena_maria.fantasia@roche.com, Gaeng, Nicolas1, Trita, Andrada Stefania2 |
| Source: |
Journal of Organic Chemistry. 1/16/2015, Vol. 80 Issue 2, p1249-1257. 9p. |
| Subjects: |
Copper research, Metals, Pyridine, Heterocyclic compounds, 2-Mercaptopyridine |
| Abstract: |
A new method for the straightforward synthesis of 2-amino-[1,2,4]triazolo[1,5-a]pyridines and derivatives is presented. The target products are synthesized in high yields from guanidylpyridines and analogues via copper-catalyzed N-N coupling. The present methodology shows a wide scope, tolerating not only different substituents on the pyridine ring but also different heterocylic rings such as pyrazines, pyrimidines, and pyridazines. [ABSTRACT FROM AUTHOR] |
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| Database: |
Engineering Source |
