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Gastrointestinal Toxicities With Combined Antiangiogenic and Stereotactic Body Radiation Therapy.

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Title: Gastrointestinal Toxicities With Combined Antiangiogenic and Stereotactic Body Radiation Therapy.
Authors: Pollom, Erqi L.1, Deng, Lei1, Pai, Reetesh K.2, Brown, J. Martin1, Giaccia, Amato1, Jr.Loo, Billy W.1, Shultz, David B.1, Le, Quynh Thu1, Koong, Albert C.1, Chang, Daniel T.1 dtchang@stanford.edu
Source: International Journal of Radiation Oncology, Biology, Physics. Jul2015, Vol. 92 Issue 3, p568-576. 9p.
Subjects: Stereotactic radiotherapy, Gastrointestinal diseases, Targeted drug delivery, Cancer patients, Cancer treatment, Toxicity testing
Abstract: Combining the latest targeted biologic agents with the most advanced radiation technologies has been an exciting development in the treatment of cancer patients. Stereotactic body radiation therapy (SBRT) is an ablative radiation approach that has become established for the treatment of a variety of malignancies, and it has been increasingly used in combination with biologic agents, including those targeting angiogenesis-specific pathways. Multiple reports have emerged describing unanticipated toxicities arising from the combination of SBRT and angiogenesis-targeting agents, particularly of late luminal gastrointestinal toxicities. In this review, we summarize the literature describing these toxicities, explore the biological mechanism of action of toxicity with the combined use of antiangiogenic therapies, and discuss areas of future research, so that this combination of treatment modalities can continue to be used in broader clinical contexts. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
Description
Abstract:Combining the latest targeted biologic agents with the most advanced radiation technologies has been an exciting development in the treatment of cancer patients. Stereotactic body radiation therapy (SBRT) is an ablative radiation approach that has become established for the treatment of a variety of malignancies, and it has been increasingly used in combination with biologic agents, including those targeting angiogenesis-specific pathways. Multiple reports have emerged describing unanticipated toxicities arising from the combination of SBRT and angiogenesis-targeting agents, particularly of late luminal gastrointestinal toxicities. In this review, we summarize the literature describing these toxicities, explore the biological mechanism of action of toxicity with the combined use of antiangiogenic therapies, and discuss areas of future research, so that this combination of treatment modalities can continue to be used in broader clinical contexts. [ABSTRACT FROM AUTHOR]
ISSN:03603016
DOI:10.1016/j.ijrobp.2015.02.016