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Gastrointestinal Toxicities With Combined Antiangiogenic and Stereotactic Body Radiation Therapy.

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Title: Gastrointestinal Toxicities With Combined Antiangiogenic and Stereotactic Body Radiation Therapy.
Authors: Pollom, Erqi L.1, Deng, Lei1, Pai, Reetesh K.2, Brown, J. Martin1, Giaccia, Amato1, Jr.Loo, Billy W.1, Shultz, David B.1, Le, Quynh Thu1, Koong, Albert C.1, Chang, Daniel T.1 dtchang@stanford.edu
Source: International Journal of Radiation Oncology, Biology, Physics. Jul2015, Vol. 92 Issue 3, p568-576. 9p.
Subjects: Stereotactic radiotherapy, Gastrointestinal diseases, Targeted drug delivery, Cancer patients, Cancer treatment, Toxicity testing
Abstract: Combining the latest targeted biologic agents with the most advanced radiation technologies has been an exciting development in the treatment of cancer patients. Stereotactic body radiation therapy (SBRT) is an ablative radiation approach that has become established for the treatment of a variety of malignancies, and it has been increasingly used in combination with biologic agents, including those targeting angiogenesis-specific pathways. Multiple reports have emerged describing unanticipated toxicities arising from the combination of SBRT and angiogenesis-targeting agents, particularly of late luminal gastrointestinal toxicities. In this review, we summarize the literature describing these toxicities, explore the biological mechanism of action of toxicity with the combined use of antiangiogenic therapies, and discuss areas of future research, so that this combination of treatment modalities can continue to be used in broader clinical contexts. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Radiation Oncology, Biology, Physics is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
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DbLabel: Engineering Source
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PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
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  Data: Gastrointestinal Toxicities With Combined Antiangiogenic and Stereotactic Body Radiation Therapy.
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  Data: <searchLink fieldCode="AR" term="%22Pollom%2C+Erqi+L%2E%22">Pollom, Erqi L.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Deng%2C+Lei%22">Deng, Lei</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Pai%2C+Reetesh+K%2E%22">Pai, Reetesh K.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Brown%2C+J%2E+Martin%22">Brown, J. Martin</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Giaccia%2C+Amato%22">Giaccia, Amato</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Jr%2ELoo%2C+Billy+W%2E%22">Jr.Loo, Billy W.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Shultz%2C+David+B%2E%22">Shultz, David B.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Le%2C+Quynh+Thu%22">Le, Quynh Thu</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Koong%2C+Albert+C%2E%22">Koong, Albert C.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Chang%2C+Daniel+T%2E%22">Chang, Daniel T.</searchLink><relatesTo>1</relatesTo><i> dtchang@stanford.edu</i>
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Radiation+Oncology%2C+Biology%2C+Physics%22">International Journal of Radiation Oncology, Biology, Physics</searchLink>. Jul2015, Vol. 92 Issue 3, p568-576. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Stereotactic+radiotherapy%22">Stereotactic radiotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Gastrointestinal+diseases%22">Gastrointestinal diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Targeted+drug+delivery%22">Targeted drug delivery</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+patients%22">Cancer patients</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+treatment%22">Cancer treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Toxicity+testing%22">Toxicity testing</searchLink>
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  Data: Combining the latest targeted biologic agents with the most advanced radiation technologies has been an exciting development in the treatment of cancer patients. Stereotactic body radiation therapy (SBRT) is an ablative radiation approach that has become established for the treatment of a variety of malignancies, and it has been increasingly used in combination with biologic agents, including those targeting angiogenesis-specific pathways. Multiple reports have emerged describing unanticipated toxicities arising from the combination of SBRT and angiogenesis-targeting agents, particularly of late luminal gastrointestinal toxicities. In this review, we summarize the literature describing these toxicities, explore the biological mechanism of action of toxicity with the combined use of antiangiogenic therapies, and discuss areas of future research, so that this combination of treatment modalities can continue to be used in broader clinical contexts. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Radiation Oncology, Biology, Physics is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=103021888
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        Value: 10.1016/j.ijrobp.2015.02.016
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      – SubjectFull: Stereotactic radiotherapy
        Type: general
      – SubjectFull: Gastrointestinal diseases
        Type: general
      – SubjectFull: Targeted drug delivery
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      – SubjectFull: Cancer patients
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      – SubjectFull: Cancer treatment
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      – SubjectFull: Toxicity testing
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      – TitleFull: Gastrointestinal Toxicities With Combined Antiangiogenic and Stereotactic Body Radiation Therapy.
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              Text: Jul2015
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